Evaluation of Prostate Specific Membrane Antigen (PSMA) in HER2-negative, Androgen Receptor (AR)-Positive Metastatic Breast Cancer With 18F-DCFPyL PSMA-based PET/CT

Who is this study for? Patients with Breast Cancer
What treatments are being studied? 18F-DCFPyL
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The purpose of this research is to determine the expression of prostate specific membrane antigen (PSMA) in human epidermal growth factor receptor 2 (HER2)-negative, androgen receptor (AR)-positive metastatic breast cancer, and to determine its role in resistance to the anti-androgen, bicalutamide. The investigators hypothesize that PSMA expression will correlate with resistance to anti-androgen therapies, as has been documented in prostate cancer, and this can be used to select patients most likely to benefit from these therapies in future clinical trials. 15 people with HER2-negative, AR-positive metastatic breast cancer will be enrolled and be on study for about 3 days.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients diagnosed with metastatic HER2-negative breast cancer AR expression of ≥ 10%

Locations
United States
Wisconsin
University of Wisconsin School of Medicine and Public Health
RECRUITING
Madison
Contact Information
Primary
Radiology Studies
radstudy@uwhealth.org
608-282-8349
Time Frame
Start Date: 2021-05-24
Estimated Completion Date: 2025-11
Participants
Target number of participants: 13
Treatments
Experimental: 18F-DCFPyL PSMA-based PET/CT
* 18F-DCFPyL whole body PET/CT scan~* Review of relevant imaging and medical record information~* Blood draw for circulating tumor cells (CTCs)~* Analysis of diagnostic tissue specimens
Related Therapeutic Areas
Sponsors
Leads: University of Wisconsin, Madison

This content was sourced from clinicaltrials.gov