Evaluation of PSMA Expression in Triple Negative Breast Cancer Patients Using 18 F-DCFPyL-PET/CT

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Female \>= 18 years of age

• Patients in distantly metastatic TNBC based on the initial diagnosis biopsy.

• Patient should have FDG positive metastatic lesions on the initial PET/CT scan performed in this study to be further included.

Locations
United States
Iowa
University of Iowa Healthcare
RECRUITING
Iowa City
Contact Information
Primary
Ahmad Shariftabrizi, M.D.
ashariftabrizi@uiowa.edu
319-887-4942
Backup
Elina Shrestha
eshrestha@uiowa.edu
319 335 0114
Time Frame
Start Date: 2024-08-29
Estimated Completion Date: 2026-08-29
Participants
Target number of participants: 30
Treatments
Experimental: PET Imaging
Triple negative breast cancer patients will undergo FDG PET/CT and Pyl PET/Ct
Sponsors
Leads: Ahmad Shariftabrizi
Collaborators: Progenics Pharmaceuticals, Inc.

This content was sourced from clinicaltrials.gov

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