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Evaluation of PSMA Expression in Triple Negative Breast Cancer Patients Using 18 F-DCFPyL-PET/CT

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The purpose of this research is to determine the expression of Prostate Specific Membrane Antigen(PSMA) in metastatic Triple Negative Breast Cancer (TNBC) patients using Fludeoxyglucose F18 (FDG) PET/CT as the gold standard. The investigators hypothesize that most lesions in metastatic TNBC are PSMA-avid; and thus PSMA-based radionuclide therapy can be a valid treatment option for TNBC, and clinical trials can be designed for this purpose. Thirty metastatic TNBC patients will be enrolled and will be on the study for maximum of 4 weeks.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Female \>= 18 years of age

• Patients in distantly metastatic TNBC based on the initial diagnosis biopsy.

• Patient should have FDG positive metastatic lesions on the initial PET/CT scan performed in this study to be further included.

Locations
United States
Iowa
University of Iowa Healthcare
RECRUITING
Iowa City
Contact Information
Primary
Ahmad Shariftabrizi, M.D.
ashariftabrizi@uiowa.edu
319-887-4942
Backup
Elina Shrestha
eshrestha@uiowa.edu
319 335 0114
Time Frame
Start Date: 2024-08-29
Estimated Completion Date: 2026-12-29
Participants
Target number of participants: 30
Treatments
Experimental: PET Imaging of breast cancer patients
Triple negative breast cancer patients will undergo FDG PET/CT and Pyl PET/Ct
Sponsors
Leads: Ahmad Shariftabrizi
Collaborators: Progenics Pharmaceuticals, Inc.

This content was sourced from clinicaltrials.gov