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Metabotyping of a Functional Food, Broccoli Microgreen, in Obese Breast Cancer Survivors

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Obesity can pose significant challenges to maintaining long-term health in cancer survivors by increasing their risk of cancer coming back. Eating a healthy diet is an important way to help manage weight and improve overall health. Broccoli microgreens (BMG) are young broccoli plants packed with nutrients, and research suggests they may help prevent cancer. Previous studies in mice showed that BMG can improve gut health and metabolism, leading to better health outcomes in obese animals. This study will test whether BMG can be a useful addition to the diet of obese breast cancer (BC) survivors who have a higher risk of their cancer returning. 24 obese BC survivors will be invited to eat one serving (one cup, \ 57 gram) of fresh BMG every day for two weeks. This will help understand if people can stick to this diet, how their bodies respond, and whether it affects metabolism and inflammation-two key factors linked to cancer risk. Biological markers such as body fat, glucose and lipids as well as gut bacterial changes will be analyzed to see how BMG affects individual health. This study may help create new diet strategies to improve health, reduce cancer risk, and support long-term recovery in cancer patients who are overweight or obese. In the future, this research could help doctors personalize nutrition plans to better support cancer survivors.

Eligibility
Participation Requirements
Sex: Female
Healthy Volunteers: f
View:

• Female

• Had a diagnosis of breast cancer (Stage I-III)

• 2 to 60 months post-curative treatment (surgery, chemotherapy, and/or radiation)

• BMI \> 30 kg/m² (obese classification)

• Willing to avoid cruciferous vegetables during the study

• Able to sign an IRB-approved consent form

Locations
United States
Maryland
Breast Evaluation and Treatment Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center
RECRUITING
Baltimore
Contact Information
Primary
Yuanyuan (Rose) Li, M.D., Ph.D.
roseli15@umd.edu
13014050776
Time Frame
Start Date: 2025-12-03
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 24
Treatments
Experimental: BMG
All participants are in BMG group and will consume one serving size (one cup, \~57 gram) of raw BMG daily for 2-week period of time.
Related Therapeutic Areas
Sponsors
Collaborators: University of Maryland, College Park
Leads: University of Maryland, Baltimore

This content was sourced from clinicaltrials.gov