Randomized Clinical Trial on the Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The treatment of colorectal cancer, in the absence of metastases, is primarily based on surgical removal. Colorectal surgery, which involves resecting part of the intestine and restoring intestinal continuity, carries a risk of complications. This study aims to evaluate whether oral supplementation with a postbiotic at a dose of 900 mg for 7 days prior to surgery reduces the rate of postoperative complications.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Individuals diagnosed with malignant neoplasm of the large intestine, specifically adenocarcinoma.
• Patients over 18 years of age, of both sexes.
• Patients who agree to participate in the study and sign the informed consent form.
Locations
Other Locations
Brazil
A.C.Camargo Cancer Center
RECRUITING
São Paulo
Contact Information
Primary
Samuel A Junior, MD, PhD
samuel.aguiar@accamargo.org.br
+5511 2189-5020
Backup
Bruna E Catin Kupper, PhD
bruna.catin@accamargo.org.br
+5511 2189-5010
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 164
Treatments
Placebo_comparator: Placebo group
Participants will receive three oral capsules per day, containing no active substance and identical in appearance to the study capsules, for seven consecutive days.
Experimental: Oral postbiotic supplementation ( Butyrate)
The formulation will contain tributyrin as the active compound, which acts directly on the large intestine. Tributyrin serves as a source of butyrate, a short-chain fatty acid. Total daily dose of 900 mg, divided into three 300 mg capsules, for seven consecutive days.
Related Therapeutic Areas
Sponsors
Leads: AC Camargo Cancer Center