Molecular Genetics and Epidemiology of Pancreatic Cancer in Ashkenazi Jewish Patients
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The aim of this study is to determine the frequency of the three most common BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) genetic mutations that are commonly found in Ashkenazi Jewish patients with pancreatic cancer. Testing for BRCA1 and BRCA2 mutations in relatives of hereditary pancreatic cancer patients may have a significant impact; allowing for early screening, treatment, and resection of pre-malignant tissue or malignant lesions.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 85
Healthy Volunteers: f
View:
• Patients diagnosed with pancreatic cancer.
• Patients are of Ashkenazi Jewish descent.
• Patients have been Columbia Pancreatic Cancer Prevention Program Registry and Tissue Bank for High-Risk Individuals (IRB-AAAA6154).
Locations
United States
New York
Columbia University Medical Center
RECRUITING
New York
Contact Information
Primary
Fay Kastrinos, MD
fk18@columbia.edu
212-305-1021
Backup
Vilma Rosario
vr2222@columbia.edu
212-305-6033
Time Frame
Start Date: 2008-01
Estimated Completion Date: 2027-12
Participants
Target number of participants: 100
Treatments
Pancreatic cancer and Ashkenazi decent
Patients with pancreatic cancer will be asked to join the study if they identify themselves as being of Ashkenazi descent, as well as patients at a high-risk of pancreas cancer based on family history, and will be followed from the time of diagnosis.
Related Therapeutic Areas
Sponsors
Leads: Columbia University