Undifferentiated Pleomorphic Sarcoma
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Undifferentiated Pleomorphic Sarcoma Overview

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What is the definition of Undifferentiated Pleomorphic Sarcoma?
Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma, is a rare, aggressive soft tissue or bone cancer that usually occurs in the arms or legs in the sixth or seventh decade of life.
What are the symptoms of Undifferentiated Pleomorphic Sarcoma?
Symptoms of undifferentiated pleomorphic sarcoma may include the presence of a mostly painless, rapidly enlarging nodule in the lower extremities (especially the thigh), upper arms, head and neck, retroperitoneum, viscera, distal or proximal femur (upper leg), proximal tibia (lower leg), or humerus (upper arm). Additional symptoms of undifferentiated pleomorphic sarcoma may include pain, swelling, malaise, lack of appetite, constipation, fever, and weight loss.
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What are the current treatments for Undifferentiated Pleomorphic Sarcoma?
Treatment for undifferentiated pleomorphic sarcoma depends on the location but may include surgery, radiation therapy, chemotherapy (ifosfamide, trabectedin, dacarbazine, and pazopanib), targeted therapy, and immunotherapy.
Who are the top Undifferentiated Pleomorphic Sarcoma Local Doctors?
Elite in Undifferentiated Pleomorphic Sarcoma
Elite in Undifferentiated Pleomorphic Sarcoma
Referral may be required

Rockefeller Outpatient Pavilion

160 E 53rd St, 
New York, NY 
646-583-3648
Languages Spoken:
English
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Accepting New Patients
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Sandra D'angelo is an Oncologist practicing medicine in New York, New York. Dr. D'angelo is rated as an Elite provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. She is also highly rated in 33 other conditions, according to our data. Her clinical expertise encompasses Synovial Sarcoma, Adult Soft Tissue Sarcoma, Liposarcoma, Merkel Cell Carcinoma, and Liver Embolization. Dr. D'angelo is currently accepting new patients.

Elite in Undifferentiated Pleomorphic Sarcoma
Elite in Undifferentiated Pleomorphic Sarcoma
Referral may be required

Rockefeller Outpatient Pavilion

160 E 53rd St, 
New York, NY 
929-379-4794
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Mark Dickson is an Oncologist practicing medicine in New York, New York. Dr. Dickson is rated as an Elite provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. He is also highly rated in 28 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Undifferentiated Pleomorphic Sarcoma, Synovial Sarcoma, and Endoscopy. Dr. Dickson is currently accepting new patients.

 
 
 
 
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Elite in Undifferentiated Pleomorphic Sarcoma
Elite in Undifferentiated Pleomorphic Sarcoma
Referral may be required

Duke Cancer Center

20 Duke Medicine Cir, 
Durham, NC 
919-681-6900
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Richard Riedel is an Oncologist practicing medicine in Durham, North Carolina. Dr. Riedel is rated as an Elite provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. He is also highly rated in 30 other conditions, according to our data. His clinical expertise encompasses Adult Soft Tissue Sarcoma, Liposarcoma, Desmoid Tumor, and Angiosarcoma. Dr. Riedel is board certified in American Board Of Internal Med, Internal Medicine and American Board Of Internal Med, Medical Oncology. Dr. Riedel is currently accepting new patients.

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What are the latest Undifferentiated Pleomorphic Sarcoma Clinical Trials?
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Dedifferentiated Liposarcoma (DDLPS), Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Dedifferentiated Liposarcoma (DDLPS), Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
Enrollment Status: Recruiting
Publish Date: September 08, 2026
Intervention Type: Procedure, Drug, Biological
Study Phase: Phase 3

Summary: This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that ...

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A Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144 or LN-145) for Patients With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma
A Pilot Trial of Autologous Tumor Infiltrating Lymphocytes (LN-144 or LN-145) for Patients With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, Dedifferentiated Liposarcoma, or Angiosarcoma
Enrollment Status: Recruiting
Publish Date: July 13, 2026
Intervention Type: Biological
Study Phase: Phase 1

Summary: This is an open label study evaluating lifileucel (LN-144) in patients with metastatic uveal melanoma.

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