Undifferentiated Pleomorphic Sarcoma Overview

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Learn About Undifferentiated Pleomorphic Sarcoma

What is the definition of Undifferentiated Pleomorphic Sarcoma?
Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma, is a rare, aggressive soft tissue or bone cancer that usually occurs in the arms or legs in the sixth or seventh decade of life.
What are the symptoms of Undifferentiated Pleomorphic Sarcoma?
Symptoms of undifferentiated pleomorphic sarcoma may include the presence of a mostly painless, rapidly enlarging nodule in the lower extremities (especially the thigh), upper arms, head and neck, retroperitoneum, viscera, distal or proximal femur (upper leg), proximal tibia (lower leg), or humerus (upper arm). Additional symptoms of undifferentiated pleomorphic sarcoma may include pain, swelling, malaise, lack of appetite, constipation, fever, and weight loss.
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What are the current treatments for Undifferentiated Pleomorphic Sarcoma?
Treatment for undifferentiated pleomorphic sarcoma depends on the location but may include surgery, radiation therapy, chemotherapy (ifosfamide, trabectedin, dacarbazine, and pazopanib), targeted therapy, and immunotherapy.
Who are the top Undifferentiated Pleomorphic Sarcoma Local Doctors?
Jose R. Alemar
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Jose R. Alemar
Oncology | Hematology
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Jose R. Alemar
Oncology | Hematology

Florida Oncology & Hematology

701 Enterprise Rd E, Bldg 300, 
Safety Harbor, FL 
 (1.6 mi)
727-223-7485
Languages Spoken:
English, Spanish
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Accepting New Patients
Offers Telehealth

Jose Alemar is an Oncologist and a Hematologist in Safety Harbor, Florida. Dr. Alemar and is rated as an Experienced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Pleuropulmonary Blastoma, Lung Cancer, Muscle Invasive Bladder Cancer, and Urothelial Cancer. Dr. Alemar is currently accepting new patients.

Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Hassan M. Ebrahim
Hematology Oncology | Hematology | Oncology
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Hassan M. Ebrahim
Hematology Oncology | Hematology | Oncology

Baycare Medical Group, Inc.

2461 Enterprise Rd, Suite C, 
Clearwater, FL 
 (2.9 mi)
727-725-5060
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Hassan Ebrahim is a Hematologist Oncology specialist and a Hematologist in Clearwater, Florida. Dr. Ebrahim and is rated as an Experienced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Inflammatory Breast Cancer, Pleuropulmonary Blastoma, Lung Cancer, Angiosarcoma, and Bone Marrow Aspiration. Dr. Ebrahim is currently accepting new patients.

 
 
 
 
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Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Akm M. Hossain
Hematology Oncology | Psychiatry | Hematology
Experienced in Undifferentiated Pleomorphic Sarcoma
Dr. Akm M. Hossain
Hematology Oncology | Psychiatry | Hematology

Baycare Medical Group, Inc.

2461 Enterprise Rd, Suite C, 
Clearwater, FL 
 (2.9 mi)
727-725-5060
Languages Spoken:
English, Bengali
See accepted insurances
Accepting New Patients
Offers Telehealth

Akm Hossain is a Hematologist Oncology specialist and a Psychiatrist in Clearwater, Florida. Dr. Hossain and is rated as an Experienced provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Childhood Iron Deficiency Anemia, Breast Cancer, Colorectal Cancer, and Sickle Cell Disease. Dr. Hossain is currently accepting new patients.

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What are the latest Undifferentiated Pleomorphic Sarcoma Clinical Trials?
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
Enrollment Status: Recruiting
Publish Date: February 24, 2025
Intervention Type: Procedure, Drug, Biological
Study Phase: Phase 3

Summary: This phase II trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that cannot be removed by surgery (unresecta...

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Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma
Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma
Enrollment Status: Recruiting
Publish Date: January 31, 2025
Intervention Type: Device
Study Phase: Not Applicable

Summary: This study is a single site, single-arm, feasibility study to evaluate the safety and efficacy of MRgFUS using the ExAblate 2100 System for the partial ablation of undifferentiated pleomorphic sarcomas.

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