Undifferentiated Pleomorphic Sarcoma
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Undifferentiated Pleomorphic Sarcoma Overview

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What is the definition of Undifferentiated Pleomorphic Sarcoma?
Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma, is a rare, aggressive soft tissue or bone cancer that usually occurs in the arms or legs in the sixth or seventh decade of life.
What are the symptoms of Undifferentiated Pleomorphic Sarcoma?
Symptoms of undifferentiated pleomorphic sarcoma may include the presence of a mostly painless, rapidly enlarging nodule in the lower extremities (especially the thigh), upper arms, head and neck, retroperitoneum, viscera, distal or proximal femur (upper leg), proximal tibia (lower leg), or humerus (upper arm). Additional symptoms of undifferentiated pleomorphic sarcoma may include pain, swelling, malaise, lack of appetite, constipation, fever, and weight loss.
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What are the current treatments for Undifferentiated Pleomorphic Sarcoma?
Treatment for undifferentiated pleomorphic sarcoma depends on the location but may include surgery, radiation therapy, chemotherapy (ifosfamide, trabectedin, dacarbazine, and pazopanib), targeted therapy, and immunotherapy.
Who are the top Undifferentiated Pleomorphic Sarcoma Local Doctors?
Richard F. Riedel
Elite in Undifferentiated Pleomorphic Sarcoma
Elite in Undifferentiated Pleomorphic Sarcoma

Duke Cancer Center

20 Duke Medicine Cir, 
Durham, NC 
Experience:
26+ years
Languages Spoken:
English
Offers Telehealth

I am a medical oncologist who focuses on bone and soft tissue cancers called sarcomas. I love spending time with my patients. They often have a sense of awareness about their condition that’s truly unique and rewarding. I partner with each patient so they know the full set of options available for treatment and can make an informed decision about the approach that is best for them. I’ve wanted to pursue medicine for as long as I can remember. I find cancer fascinating because of its ability to evade the immune system. The body fails to recognize cancer as being foreign. When I am not at work, I love spending time with my family and enjoy long distance running. Dr. Riedel is rated as an Elite provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Adult Soft Tissue Sarcoma, Liposarcoma, Desmoid Tumor, and Angiosarcoma.

Nicholas P. Webber
Distinguished in Undifferentiated Pleomorphic Sarcoma
Distinguished in Undifferentiated Pleomorphic Sarcoma

Aurora Orthopedics

2801 W Kinnickinnic River Pkwy, Ste 370, 
Milwaukee, WI 
Languages Spoken:
English

Nicholas Webber is an Orthopedics provider in Milwaukee, Wisconsin. Dr. Webber is rated as a Distinguished provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Osteoarthritis, Osteonecrosis, Rhabdomyosarcoma Embryonal, Hip Replacement, and Knee Replacement.

 
 
 
 
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Brent G. Witten
Distinguished in Undifferentiated Pleomorphic Sarcoma
Distinguished in Undifferentiated Pleomorphic Sarcoma

Aurora Orthopedics

975 Port Washington Rd, Ste 110, 
Grafton, WI 
Languages Spoken:
English

Brent Witten is an Orthopedics provider in Grafton, Wisconsin. Dr. Witten is rated as a Distinguished provider by MediFind in the treatment of Undifferentiated Pleomorphic Sarcoma. His top areas of expertise are Rhabdomyosarcoma Embryonal, Epithelioid Sarcoma, Undifferentiated Pleomorphic Sarcoma, Mesenchymoma, and Hip Replacement.

What are the latest Undifferentiated Pleomorphic Sarcoma Clinical Trials?
A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Dedifferentiated Liposarcoma (DDLPS), Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas

Summary: This phase III trial compares the effect of immunotherapy (pembrolizumab) plus chemotherapy (doxorubicin) to chemotherapy (doxorubicin) alone in treating patients with dedifferentiated liposarcoma (DDLPS), undifferentiated pleomorphic sarcoma (UPS) or a related poorly differentiated sarcoma that has spread from where it first started (primary site) to other places in the body (metastatic) or that ...

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