Single Bladder Instillation With Chemotherapy Following Endoscopic Treatment for Upper Tract Urothelial Carcinoma to Reduce Bladder Recurrence
The goal of this study is to evaluate the safety and oncological outcomes of single chemotherapy bladder instillation following endoscopic treatment for UTUC in UTUC suspected patients .The main aim is to determine the efficacy of a single, post URS, chemotherapy bladder instillation to reduce IVR. Participants will be given single chemotherapy bladder instillation within 24h following ureteroscopy and will follow routine follow-up for IVR which will include white light cystoscopy ;patients with suspected IVR (based on either imaging or cystoscopy) will undergo TURBT.
• Radiographic and/or cytological suspicion for UTUC
• Planned endoscopic procedure for treatment / diagnosis of UTUC
• Patients with bladder cancer history are eligible if meeting both following criteria:
⁃ No recurrence within the last two years Are not on active bladder irrigation protocol
• Patients with history of UTUC are eligible if last endoscopic treatment or RNU was \>1 year prior to enrollment
• Age ≥ 18 years
• Performance status ECOG 0-2