Urine-based Methylation Markers in the Diagnosis and Surveillance of Upper Tract Urothelial Carcinoma
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a research study to measure DNA markers in the urine of patients with upper tract urothelial cancer (UTUC) before surgery and during follow-up visits. Identifying these DNA markers could improve diagnosis before surgery, help assess risk, and predict early recurrence of the cancer. Urine samples will be de-identified and sent to Zymo/Pangea Research Corporation for analysis. The results of this test will be compared to the traditional tests in upper tract urothelial cancer, such as cells in the urine and tissue biopsy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• \>=18 years
• Primary UTUC
Locations
United States
North Carolina
Duke University
RECRUITING
Durham
Contact Information
Primary
Alireza Ghoreifinejadian, M.D.
alireza.ghoreifi@duke.edu
919-684-8111
Time Frame
Start Date: 2025-05-07
Estimated Completion Date: 2026-06
Participants
Target number of participants: 50
Treatments
Other: Patients with primary UTUC (upper tract urothelial carcinoma)
Urine DNA samples will be quantified using the Femto Human DNA Quantification Kit at baseline, 3 months, and 6 months.
Related Therapeutic Areas
Sponsors
Leads: Duke University