Uveal Melanoma
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Uveal Melanoma Overview

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Learn About Uveal Melanoma

What is the definition of Uveal Melanoma?
Intraocular melanoma is a cancer of the pigment-producing cells (melanocytes) in the middle layer of the eye, called the uveal tract. The uveal tract has 3 main parts: (1) the choroid (the tissue layer filled with blood vessels); (2) the ciliary body (the ring of muscle tissue that changes the size of the pupil and the shape of the lens); and (3) the iris (the colored part of the eye). Most cases of Intraocular melanoma develop in the choroid, called choroidal melanoma. The ciliary body is less commonly a site of origin, and the iris is the least common. Each manifests with different clinical features and symptoms.
What are the alternative names for Uveal Melanoma?
  • Intraocular melanoma
  • Melanoma of the Uvea
  • Uveal melanoma
Who are the top Uveal Melanoma Local Doctors?
Elite in Uveal Melanoma
Dr. Richard D. Carvajal
Oncology
Elite in Uveal Melanoma
Dr. Richard D. Carvajal
Oncology
Referral may be required

Northwell Health Center For Advanced Medicine, RJ Zuckerberg Cancer Center

450 Lakeville Road, Entrance B, 
Lake Success, NY 
516-734-8900
Languages Spoken:
English
See accepted insurances
Offers Telehealth

Richard Carvajal is an Oncologist practicing medicine in Lake Success, New York. Dr. Carvajal is rated as an Elite provider by MediFind in the treatment of Uveal Melanoma. He is also highly rated in 8 other conditions, according to our data. His clinical expertise encompasses Metastatic Uveal Melanoma, Uveal Melanoma, Melanoma of the Eye, Melanoma, and Tissue Biopsy. Dr. Carvajal is board certified in American Board Of Internal Medicine/Medical Oncology.

Elite in Uveal Melanoma
Dr. Marlana M. Orloff
Hematology | Oncology
Elite in Uveal Melanoma
Dr. Marlana M. Orloff
Hematology | Oncology
Referral may be required

Jefferson Cancer - Honickman Center

1101 Chestnut Street, Floor 14, 
Philadelphia, PA 
215-955-8874
Languages Spoken:
English
See accepted insurances
Accepting New Patients
Offers Telehealth

Marlana Orloff is an Oncologist practicing medicine in Philadelphia, Pennsylvania. Dr. Orloff is rated as an Elite provider by MediFind in the treatment of Uveal Melanoma. She is also highly rated in 5 other conditions, according to our data. Her clinical expertise encompasses Metastatic Uveal Melanoma, Uveal Melanoma, Melanoma of the Eye, Melanoma, and Liver Embolization. Dr. Orloff is board certified in Medical Oncology and Internal Medicine. Dr. Orloff is currently accepting new patients.

 
 
 
 
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Elite in Uveal Melanoma
Dr. Hans E. Grossniklaus
Ophthalmology
Elite in Uveal Melanoma
Dr. Hans E. Grossniklaus
Ophthalmology
Referral may be required

Emory Eye Center

1365 Clifton Road Northeast, BldgB, 
Atlanta, GA 
404-778-2020
Experience:
46+ years
Languages Spoken:
English
See accepted insurances

Hans Grossniklaus is an Ophthalmologist practicing medicine in Atlanta, Georgia. He has been practicing medicine for over 46 years. Dr. Grossniklaus is rated as an Elite provider by MediFind in the treatment of Uveal Melanoma. He is also highly rated in 10 other conditions, according to our data. His clinical expertise encompasses Melanoma of the Eye, Uveal Melanoma, Metastatic Uveal Melanoma, Vitrectomy, and Corneal Transplant. Dr. Grossniklaus is board certified in American Board Of Pathology, 1987.

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What are the latest Uveal Melanoma Clinical Trials?
Phase 2 Trial of Adjuvant Quisinostat in High-Risk Uveal Melanoma
Phase 2 Trial of Adjuvant Quisinostat in High-Risk Uveal Melanoma
Enrollment Status: Recruiting
Publish Date: June 18, 2026
Intervention Type: Drug
Study Phase: Phase 2

Summary: The purpose of this study is to see if giving participants quisinostat will prevent participants' uveal melanoma tumor from spreading. The researchers want to find out the effects that quisinostat has on participants' condition.

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A Phase I/II Study of Tebentafusp-tebn in Combination With Liver-Directed Therapies for the Treatment of Metastatic Uveal Melanoma
A Phase I/II Study of Tebentafusp-tebn in Combination With Liver-Directed Therapies for the Treatment of Metastatic Uveal Melanoma
Enrollment Status: Recruiting
Publish Date: June 16, 2026
Intervention Type: Drug
Study Phase: Phase 1/Phase 2

Summary: This study is a multicenter, open label phase I/ II trial to assess the safety and clinical efficacy of tebentafusp-tebn in combination with liver-directed therapies in HLA-A\*0201 positive patients with metastatic uveal melanoma. In Part 1 of the study, the Prinicipal Investigator will investigate the safety and efficacy of tebentafusp-tebn in combination with hepatic IE in patients with a low to...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center