Condition 101 About Uveitis

What is the definition of Uveitis?

Uveitis is swelling and inflammation of the uvea. The uvea is the middle layer of the wall of the eye. The uvea supplies blood for the iris at the front of the eye and the retina in the back of the eye.

What are the alternative names for Uveitis?

Iritis; Pars planitis; Choroiditis; Chorioretinitis; Anterior uveitis; Posterior uveitis; Iridocyclitis

What are the causes for Uveitis?

Uveitis can be caused by autoimmune disorders. These diseases occur when the body's immune system attacks and destroys healthy body tissue by mistake. Examples are:

  • Ankylosing spondylitis
  • Behcet disease
  • Psoriasis
  • Reactive arthritis
  • Rheumatoid arthritis
  • Sarcoidosis
  • Ulcerative colitis

Uveitis can also be caused by infections such as:

  • AIDS
  • Cytomegalovirus (CMV) retinitis
  • Herpes zoster infection
  • Histoplasmosis
  • Kawasaki disease
  • Syphilis
  • Toxoplasmosis
  • Tuberculosis

Exposure to toxins or injury can also cause uveitis. In many cases, the cause is unknown.

Often the inflammation is limited to only part of the uvea. The most common form of uveitis involves inflammation of the iris, in the front part of the eye. In this case, the condition is called iritis. In most cases, it occurs in healthy people. The disorder may affect only one eye. It is most common in young and middle-aged people.

Posterior uveitis affects the back part of the eye. It involves primarily the choroid. This is the layer of blood vessels and connective tissue in the middle layer of the eye. This type of uveitis is called choroiditis. If the retina is also involved, it is called chorioretinitis.

Another form of uveitis is pars planitis. Inflammation occurs in the area called the pars plana, which is located between the iris and the choroid. Pars planitis most often occurs in young men. It is generally not associated with any other disease. However, it may be linked to Crohn disease and possibly multiple sclerosis.

What are the symptoms for Uveitis?

Uveitis can affect one or both eyes. Symptoms depend on which part of the uvea is inflamed. Symptoms may develop rapidly and can include:

  • Blurred vision
  • Dark, floating spots in the vision
  • Eye pain
  • Redness of the eye
  • Sensitivity to light

What are the current treatments for Uveitis?

Iritis and irido-cyclitis (anterior uveitis) is most often mild. Treatment may involve:

  • Dark glasses
  • Eye drops that dilate the pupil to relieve pain
  • Steroid eye drops

Pars planitis is often treated with steroid eye drops. Other medicines, including steroids taken by mouth, may be used to help suppress the immune system.

Posterior uveitis treatment depends on the underlying cause. It almost always includes steroids taken by mouth.

If the uveitis is caused by a body-wide (systemic) infection, you may be given antibiotics. You may also be given powerful anti-inflammatory medicines called corticosteroids. Sometimes certain types of immune-suppressant drugs are used to treat severe uveitis.

What is the outlook (prognosis) for Uveitis?

With proper treatment, most attacks of anterior uveitis go away in a few days to weeks. However, the problem often returns.

Posterior uveitis may last from months to years. It may cause permanent vision damage, even with treatment.

What are the possible complications for Uveitis?

Complications may include:

  • Cataracts
  • Fluid within the retina
  • Glaucoma
  • Irregular pupil
  • Retinal detachment
  • Vision loss

When should I contact a medical professional for Uveitis?

Symptoms that need urgent medical care are:

  • Eye pain
  • Reduced vision

How do I prevent Uveitis?

If you have a body-wide (systemic) infection or disease, treating the condition may prevent uveitis.

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REFERENCES

American Academy of Ophthalmology website. Treatment of uveitis. eyewiki.aao.org/Treatment_of_Uveitis. Updated December 16, 2019. Accessed September 15, 2020.

Cioffi GA, Liebmann JM. Diseases of the visual system. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 395.

Durand ML. Infectious causes of uveitis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 115.

Gery I, Chan C-C. Mechanisms of uveitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 7.2.

Read RW. General approach to the uveitis patient and treatment strategies. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 7.3.

Latest Advances On Uveitis

  • Condition: Refractory Noninfectious Uveitis
  • Journal: Yonsei medical journal
  • Treatment Used: Adalimumab
  • Number of Patients: 14
  • Published —
This study tested the safety and efficacy of using adalimumab to treat patients with refractory noninfectious uveitis.
  • Condition: Glaucoma
  • Journal: Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
  • Treatment Used: Transcleral Diode Cyclophotocoagulation
  • Number of Patients: 24
  • Published —
This study assessed the safety of diode cyclophotocoagulation (CPC) in the treatment of patients with glaucoma.

Clinical Trials For Uveitis

Clinical Trial
  • Status: Enrolling by invitation
  • Participants: 1000
  • Start Date: February 15, 2021
Biomarkers in Ocular Inflammation and Uveitis
Clinical Trial
  • Status: Recruiting
  • Participants: 150
  • Start Date: February 15, 2021
Microbiome as a ThErapeutic Response Biomarker