Van Der Woude SyndromeSymptoms, Doctors, Treatments, Advances & More
Learn About Van Der Woude Syndrome
Van der Woude syndrome is a condition that affects the development of the face. Many people with this disorder are born with either a cleft lip or a cleft palate (an opening in the upper lip or roof of the mouth), or both. Affected individuals usually have depressions (pits) near the center of the lower lip, which may appear moist due to the presence of salivary and mucous glands in the pits. Small mounds of tissue on the lower lip may also occur. In some cases, people with van der Woude syndrome have missing teeth.
Variations (also known as mutations) in the IRF6 gene cause most cases of van der Woude syndrome. The IRF6 gene provides instructions for making a protein that plays an important role in early development. This protein is a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of particular genes. The IRF6 protein is active in cells that give rise to tissues in the head and face. It is also involved in the development of other parts of the body, including the skin and genitals.
Van der Woude syndrome is believed to occur in 1 in 35,000 to 1 in 100,000 people, based on data from Europe, Asia, and Africa. Van der Woude syndrome is the most common cause of cleft lip and palate resulting from genetic variations.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In most cases, an affected person has one parent with the condition. Occasionally, an individual who has a copy of the altered gene does not show any signs or symptoms of the disorder.
Ear Nose And Throat Associates, PC
Bruce Abkes is an Otolaryngologist practicing medicine in Johnson City, Tennessee. Dr. Abkes is rated as an Advanced provider by MediFind in the treatment of Van Der Woude Syndrome. He is also highly rated in 37 other conditions, according to our data. His clinical expertise encompasses Hyperparathyroidism, Familial Isolated Hyperparathyroidism, Osteitis Fibrosa, and Neonatal Severe Hyperparathyroidism. Dr. Abkes is board certified in American Board Of Otolaryngology.
Ene-choo Tan practices practicing medicine in Singapore, Singapore. Tan is rated as an Elite expert by MediFind in the treatment of Van Der Woude Syndrome. They are also highly rated in 11 other conditions, according to our data. Their clinical expertise encompasses Van Der Woude Syndrome, Coffin-Siris Syndrome, Epidermal Nevus, Epidermolytic Hyperkeratosis, and Hysterectomy.
Cook Childrens Dodson Surgery Center
Jeffrey Murray is a Hematologist and an Oncologist practicing medicine in Fort Worth, Texas. Dr. Murray is rated as an Elite provider by MediFind in the treatment of Van Der Woude Syndrome. He is also highly rated in 4 other conditions, according to our data. His clinical expertise encompasses Van Der Woude Syndrome, Medulloblastoma, Embryonal Tumor with Multilayered Rosettes, and Glioma.
Published Date: July 07, 2022
Published By: National Institutes of Health