Application Value of Novel PET Tracers Targeting CAF in ANCA-Associated Vasculitis

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

Pulmonary and renal involvement are the most common clinical manifestations of antineutrophil cytoplasmic antibody(ANCA)-associated vasculitis (AAV). Studies have shown that both interstitial lung disease (ILD) and renal dysfunction are closely associated with poor prognosis in patients with AAV. Therefore, early identification of whether AAV patients have concomitant ILD and renal involvement is of great clinical importance for assessing disease severity, stratifying prognostic risk, and developing individualized treatment strategies. Positron emission tomography (PET) is a noninvasive molecular imaging technique that can provide decision-making support for early and accurate diagnosis, timely intervention, as well as evaluation of treatment response and prognosis. In the same individual, PET enables whole-body localization of disease in a single examination, overcoming the limitation of conventional diagnostic methods that typically assess only one region at a time, thereby facilitating patient benefit. In recent years, many novel PET tracers have been developed and introduced into clinical practice. 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) has been studied in the diagnosis of various malignant and nonmalignant diseases; it targets fibroblast activation protein (FAP) and thus reflects the distribution of cancer-associated fibroblasts (CAFs). However, its clinical significance in AAV remains to be further investigated. This study aims to use a CAF-targeted novel PET tracer to conveniently and noninvasively detect the real-time distribution of lesions in patients, providing valuable information for personalized diagnosis and treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age over 18 years;

• Meeting the 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for ANCA-associated vasculitis;

• Diagnosed with concomitant interstitial lung disease based on High-Resolution Computed Tomography (HRCT) images obtained within one year prior to enrollment, interpreted by two radiologists blinded to clinical information;

• Complete clinical information available;

• Signed and dated informed consent form;

• Willingness to comply with the study procedures and cooperate throughout the entire study process.

Locations
Other Locations
China
Ruiiin Hospital Shanghai JiaoTong University School of Medicine
RECRUITING
Shanghai
Contact Information
Primary
Hong-Lei Liu
hong-lei-liu@163.com
+8617721375702
Backup
Jiajia Hu
hjj11592@rjh.com.cn
+8613524945287
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2028-07-01
Participants
Target number of participants: 30
Treatments
ANCA-associated vasculitis with interstitial lung disease
ANCA-associated vasculitis without interstitial lung disease
ANCA-associated vasculitis with renal dysfunction
ANCA-associated vasculitis without renal dysfunction
Sponsors
Leads: Ruijin Hospital

This content was sourced from clinicaltrials.gov