The Cohort Study of East Chinese Takayasu's Arteritis (ECTA-cohort Study)

Status: Recruiting
Location: See location...
Intervention Type: Biological, Drug
Study Type: Observational
SUMMARY

The Takayasu arteritis (TA) is a rare inflammatory large vessel arteritis which often occurs women in Aisa, one of which is China. The rare cases restricted the development of intervention strategy, especially in female patients who plan to be pregnant. So investigators try to recruit as many TA participants as possible to build a TA cohort so that investigators could manage patients much more professionally and standardized and explore the better interventional strategy for a better outcome as well, with full use of blood and vascular tissues.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
View:

• onset at age ≤40 years;

• claudication of an extremity;

• decreased brachial artery pulse;

• \>10 mm Hg difference in systolic blood pressure between arms;

• a bruit over the subclavian arteries or the aorta;

• angiographic evidence of narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities.

‣ Patients should meet at least 3 of the above 6 articles.

⁃ Sign the informed consent

Locations
Other Locations
China
Department of Rheumatology in Zhongshan hospital, Fudan University
RECRUITING
Shanghai
Contact Information
Primary
Lindi Jiang, PhD
zsh-rheum@hotmail.com
+86-021-64041990
Backup
Rongyi Chen, MD
chenry825@hotmail.com
+8615221160538
Time Frame
Start Date: 2016-11-01
Estimated Completion Date: 2026-05-31
Participants
Target number of participants: 1000
Treatments
Control group
The control group mainly consists of healthy volunteers. The whole blood is obtained and frozen to detect the corresponding biochemical markers in the futures. The vascular tissues are obtained from the deserted and free abdominal aorta conjugated to the renal artery in the kidney transplantation.
sham TA group
In the TA cohort, patients are divided into two groups mainly, sham TA group and scramble TA group. The sham TA group is the TA group who is given the traditional and classical intervention or treatment and so on.
scramble TA group
Compared to sham TA group in the cohort, scramble TA group refers to TA patients who are given novel drugs or new drugs which are safe to treat other autoimmune diseases but have not been used to treat TA yet, or some new interventions and so on.
Related Therapeutic Areas
Sponsors
Leads: Shanghai Zhongshan Hospital

This content was sourced from clinicaltrials.gov

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