Learn About VIPoma

What is the definition of VIPoma?

VIPoma is a very rare cancer that usually grows from cells in the pancreas called islet cells.

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What are the alternative names for VIPoma?

Vasoactive intestinal peptide-producing tumor; VIPoma syndrome; Pancreatic endocrine tumor; Verner-Morrison syndrome; WDHA

What are the causes of VIPoma?

VIPoma causes cells in the pancreas to produce a high level of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines. It also relaxes some of the smooth muscles in the gastrointestinal system.

The exact cause of VIPomas is not known.

VIPomas are often diagnosed in adults, most commonly around age 50. Women are more likely to be affected than men. This cancer is rare. Each year, only about 1 in 10 million people are diagnosed with a VIPoma.

What are the symptoms of VIPoma?

Symptoms of VIPoma may include any of the following:

  • Abdominal pain and cramping
  • Diarrhea (watery, and often in large amounts)
  • Dehydration
  • Flushing or redness of the face
  • Muscle cramps due to low blood potassium (hypokalemia)
  • Nausea
  • Weight loss
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What are the current treatments for VIPoma?

The first goal of treatment is to correct dehydration. Fluids are often given through a vein (intravenous fluids) to replace fluids lost through diarrhea.

The next goal is to slow the diarrhea. Medicines can help control diarrhea. One such medicine is octreotide. It is a manmade form of a natural hormone that blocks the action of VIP.

The best chance of a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure the condition.

Who are the top VIPoma Local Doctors?
Highly rated in

Graduate School Of Medical Sciences, Kyushu University

Fukuoka Sanno Hospital 
Fukuoka, JP 

Tetsuhide Ito is in Fukuoka, Japan. Ito is rated as an Elite expert by MediFind in the treatment of VIPoma. They are also highly rated in 27 other conditions, according to our data. Their top areas of expertise are Pancreatic Islet Cell Tumor, Zollinger-Ellison Syndrome, VIPoma, and Neuroendocrine Tumor.

Highly rated in

University Of Vienna

Division Of Infectious Diseases And Tropical Medicine 
Vienna, AT 

Elisabeth Fabian is in Vienna, Austria. Fabian is rated as a Distinguished expert by MediFind in the treatment of VIPoma. She is also highly rated in 4 other conditions, according to our data. Her top areas of expertise are VIPoma, Low Potassium Level, Carcinoid Syndrome, and Somatostatinoma.

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Highly rated in

Institute For Clinical Diabetology

Duesseldorf, NW, DE 

Karsten Mussig is in Duesseldorf, Germany. Mussig is rated as a Distinguished expert by MediFind in the treatment of VIPoma. He is also highly rated in 15 other conditions, according to our data. His top areas of expertise are VIPoma, Maturity Onset Diabetes of the Young, Type 2 Diabetes, and Glucagonoma.

What are the support groups for VIPoma?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for VIPoma?

Surgery can usually cure VIPomas. But, in one third to one half of people, the tumor has spread by the time of diagnosis and cannot be cured.

What are the possible complications of VIPoma?

Complications may include:

  • Cancer spread (metastasis)
  • Cardiac arrest from low blood potassium level
  • Dehydration
When should I contact a medical professional for VIPoma?

If you have watery diarrhea for more than 2 to 3 days, contact your provider.

What are the latest VIPoma Clinical Trials?
Randomized Phase II Study of Everolimus Alone Versus Everolimus Plus Bevacizumab in Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors
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A Multi-center, Registration Study for Gastroenteral-Pancreatic Neuroendocrine Tumors in Taiwan
What are the Latest Advances for VIPoma?
VIPoma of the Pancreas.
Use of a somatostatin analog to improve a patient's condition and the subsequent diagnosis of pancreatic VIPoma:a case report.
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Successful Treatment of Hypokalemic Rhabdomyolysis Caused by a Pancreatic VIPoma: A Case Report.
Who are the sources who wrote this article ?

Published Date : October 16, 2020
Published By : Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Asban A, Patel AJ, Reddy S, Wang T, Balentine CJ, Chen H. Cancer of the endocrine system. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 68.

National Cancer Institute website. Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ) - health professional version. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Updated January 2, 2020. Accessed March 17, 2021.

Öberg K. Neuroendocrine tumors and related disorders. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 45.