What is the definition of VIPoma?

VIPoma is a very rare cancer that usually grows from cells in the pancreas called islet cells.

What are the alternative names for VIPoma?

Vasoactive intestinal peptide-producing tumor; VIPoma syndrome; Pancreatic endocrine tumor; Verner-Morrison syndrome; WDHA

What are the causes for VIPoma?

VIPoma causes cells in the pancreas to produce a high level of a hormone called vasoactive intestinal peptide (VIP). This hormone increases secretions from the intestines. It also relaxes some of the smooth muscles in the gastrointestinal system.

The exact cause of VIPomas is not known.

VIPomas are often diagnosed in adults, most commonly around age 50. Women are more likely to be affected than men. This cancer is rare. Each year, only about 1 in 10 million people are diagnosed with a VIPoma.

What are the symptoms for VIPoma?

Symptoms of VIPoma may include any of the following:

  • Abdominal pain and cramping
  • Diarrhea (watery, and often in large amounts)
  • Dehydration
  • Flushing or redness of the face
  • Muscle cramps due to low blood potassium (hypokalemia)
  • Nausea
  • Weight loss

What are the current treatments for VIPoma?

The first goal of treatment is to correct dehydration. Fluids are often given through a vein (intravenous fluids) to replace fluids lost through diarrhea.

The next goal is to slow the diarrhea. Medicines can help control diarrhea. One such medicine is octreotide. It is a manmade form of a natural hormone that blocks the action of VIP.

The best chance of a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure the condition.

What are the support groups for VIPoma?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for VIPoma?

Surgery can usually cure VIPomas. But, in one third to one half of people, the tumor has spread by the time of diagnosis and cannot be cured.

What are the possible complications for VIPoma?

Complications may include:

  • Cancer spread (metastasis)
  • Cardiac arrest from low blood potassium level
  • Dehydration

When should I contact a medical professional for VIPoma?

If you have watery diarrhea for more than 2 to 3 days, contact your provider.

Pancreas

REFERENCES

Asban A, Patel AJ, Reddy S, Wang T, Balentine CJ, Chen H. Cancer of the endocrine system. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 68.

National Cancer Institute website. Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ) - health professional version. www.cancer.gov/types/pancreatic/hp/pnet-treatment-pdq. Updated January 2, 2020. Accessed March 17, 2021.

Öberg K. Neuroendocrine tumors and related disorders. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 45.

  • Condition: Pancreatic VIPoma
  • Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
  • Treatment Used: Somatostatin Analog
  • Number of Patients: 1
  • Published —
This case report discusses a 68-year-old woman diagnosed with pancreatic VIPoma treated with somatostatin analog.
  • Condition: VIPoma
  • Journal: The American journal of case reports
  • Treatment Used: Surgery
  • Number of Patients: 1
  • Published —
The study researched the treatment of hypokalemic rhabdomyolysis caused by a pancreatic VIPoma.
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 1
  • Intervention Type: Device
  • Participants: 10
  • Start Date: January 1, 2018
Phase I Feasibility Trial To Study The Safety Of Sealing Resected Pancreatic Surfaces After Partial Distal Pancreatectomy Using Laser Tissue Welding
Clinical Trial
  • Status: Enrolling by invitation
  • Participants: 600
  • Start Date: March 2014
A Multi-center, Registration Study for Gastroenteral-Pancreatic Neuroendocrine Tumors in Taiwan