What is the definition of Virus Associated Hemophagocytic Syndrome?

Virus associated hemophagocytic syndrome is a very serious complication of a viral infection. Signs and symptoms of virus associated hemophagocytic syndrome, include high fever, liver problems, enlarged liver and spleen, coagulation factor abnormalities, decreased red or white blood cells and platelets (pancytopenia), and a build-up of histiocytes, a type of immune cell, in various tissues in the body resulting in the destruction of blood-producing cells (histiocytic proliferation with prominent hemophagocytosis). 

Diagnosis is based upon the signs and symptoms of the patient. The cause of the condition is not known. Treatment is challenging and approach will vary depending on the age and medical history of the patient. Complications of this syndrome can become life threatening. Related conditions (conditions with overlapping signs and symptoms), include histiocytic medullary reticulosis (HMR), familial hemophagocytic lymphohistiocytosis (FHL), and X-linked lymphoproliferative syndrome.
  • Condition: Epstein-Barr Virus-Related Hemophagocytic Lymphohistiocytosis
  • Journal: Medicine
  • Treatment Used: Ruxolitinib with the HLH-94 Protocol
  • Number of Patients: 1
  • Published —
This study presents a case of a critically ill 14-year-old girl with Epstein-Barr virus-related hemophagocytic lymphohistiocytosis who was treated with Ruxolitinib in conjunction with the HLH-94 protocol.
  • Condition: SARS CoV 2 Infection in Chronic Myelogenous Leukemia
  • Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • Treatment Used: Immunoglobulin, Steroids, and Antiviral Therapy
  • Number of Patients: 1
  • Published —
This case report describes a patient with COVID-19 and chronic myelogenous leukemia treated with intravenous immunoglobulin, steroids, and antiviral therapy.