Learn About Vulvar Cancer

What is the definition of Vulvar Cancer?

Vulvar cancer is cancer that starts in the vulva. Vulvar cancer most often affects the labia, the folds of skin outside the vagina. In some cases, vulvar cancer starts on the clitoris or in glands on the sides of the vaginal opening.

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What are the alternative names for Vulvar Cancer?

Cancer - vulva; Cancer - perineum; Cancer - vulvar; Genital warts - vulvar cancer; HPV - vulvar cancer

What are the causes of Vulvar Cancer?

Most vulvar cancers begin in skin cells called squamous cells. Other types of cancers found on the vulva are:

  • Adenocarcinoma
  • Basal cell carcinoma
  • Melanoma
  • Sarcoma

Vulvar cancer is rare. Risk factors include:

  • Human papilloma virus (HPV, or genital warts) infection in women under age 50
  • Chronic skin changes, such as lichen sclerosis or squamous hyperplasia in women over age 50
  • History of cervical cancer or vaginal cancer
  • Smoking

Women with a condition called vulvar intraepithelial neoplasia (VIN) may develop into a vulvar cancer that spreads. Most cases of VIN, though, never lead to cancer.

Other possible risk factors may include:

  • History of abnormal Pap smears
  • Having many sexual partners
  • Having first sexual intercourse at 16 or younger
What are the symptoms of Vulvar Cancer?

Women with this condition will often have itching around the vagina for years. They may have used different skin creams. They may also have bleeding or discharge outside their periods.

Other skin changes that may occur around the vulva:

  • Mole or freckle, which may be pink, red, white, or gray
  • Skin thickening or lump
  • Skin sore (ulcer) especially if non healing

Other symptoms:

  • Pain or burning with urination
  • Pain with intercourse
  • Unusual odor

Some women with vulvar cancer have no symptoms.

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What are the current treatments for Vulvar Cancer?

Treatment involves surgery to remove the cancer cells. If the tumor is large (more than 2 cm) or has grown into the skin, the lymph nodes in the groin area may also be removed.

Radiation, with or without chemotherapy, may be used to treat:

  • Advanced tumors that cannot be treated with surgery
  • Vulvar cancer that comes back
  • Women who are not medically able to undergo surgery
Who are the top Vulvar Cancer Local Doctors?
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What are the support groups for Vulvar Cancer?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for Vulvar Cancer?

Most women with vulvar cancer who are diagnosed and treated at an early stage do well. But a woman's outcome depends on:

  • The size of the tumor
  • The type of vulvar cancer
  • Whether the cancer has spread

The cancer commonly comes back at or near the site of the original tumor.

What are the possible complications of Vulvar Cancer?

Complications may include:

  • Spread of the cancer to other areas of the body
  • Side effects of radiation, surgery, or chemotherapy
When should I contact a medical professional for Vulvar Cancer?

Call your health care provider if you have any of these symptoms for more than 2 weeks:

  • Local irritation
  • Skin color change
  • Sore on the vulva
How do I prevent Vulvar Cancer?

Practicing safer sex may decrease your risk for vulvar cancer. This includes using condoms to protect against sexually transmitted infections (STIs).

A vaccine is available to protect against certain forms of HPV infection. The vaccine is approved to prevent cervical cancer and genital warts. It may help prevent other cancers linked to HPV, such as vulvar cancer. The vaccine is given to young girls before they become sexually active, and to adolescents and women up to age 45.

Routine pelvic exams can help detect vulvar cancer at an earlier stage. Earlier diagnosis improves your chances that treatment will be successful.

Female perineal anatomy
What are the latest Vulvar Cancer Clinical Trials?
Far Eastern Memorial Hospital

Summary: To assess the G9a expression in vulvar cancer

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Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.

Summary: Almost half of all women will develop an HPV infection in their lifetime. While most infections are naturally asymptomatic or cleared by the immune system, some persist and can lead to the development of cervical, vulvar, or anal lesions and eventually cancer. Screening regimens for these lesions are currently only in place for the cervix through regular Pap tests. These Pap tests usually involve ...

What are the Latest Advances for Vulvar Cancer?
Results of laparoscopic pelvic exenterations.
Clinical analysis of 23 cases with simultaneous double primary gynecological malignant tumors.
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Topical imiquimod versus surgery for vulvar intraepithelial neoplasia: a multicentre, randomised, phase 3, non-inferiority trial.
Who are the sources who wrote this article ?

Published Date: January 01, 2022
Published By: Howard Goodman, MD, Gynecologic Oncology, Florida Cancer Specialists & Research Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Frumovitz M. Neoplastic diseases of the vulva and vagina. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 30.

Jhingran A, Russell AH, Seiden MV, et al. Cancers of the cervix, vulva, and vagina. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 84.

National Comprehensive Cancer Network website. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Vulvar cancer (squamous cell cardinoma) Version 1.2022 – October 7, 2021 www.nccn.org/professionals/physician_gls/pdf/vulvar.pdf.

National Cancer Institute website. Vulvar cancer treatment (PDQ) - health professional version. www.cancer.gov/types/vulvar/hp/vulvar-treatment-pdq. Updated January 25, 2022. Accessed April 21, 2022.