What is the definition of Vulvar Cancer?

Vulvar cancer is cancer that starts in the vulva. Vulvar cancer most often affects the labia, the folds of skin outside the vagina. In some cases, vulvar cancer starts on the clitoris or in glands on the sides of the vaginal opening.

What are the alternative names for Vulvar Cancer?

Cancer - vulva; Cancer - perineum; Cancer - vulvar; Genital warts - vulvar cancer; HPV - vulvar cancer

What are the causes for Vulvar Cancer?

Most vulvar cancers begin in skin cells called squamous cells. Other types of cancers found on the vulva are:

  • Adenocarcinoma
  • Basal cell carcinoma
  • Melanoma
  • Sarcoma

Vulvar cancer is rare. Risk factors include:

  • Human papilloma virus (HPV, or genital warts) infection in women under age 50
  • Chronic skin changes, such as lichen sclerosis or squamous hyperplasia in women over age 50
  • History of cervical cancer or vaginal cancer
  • Smoking

Women with a condition called vulvar intraepithelial neoplasia (VIN) have a high risk of developing vulvar cancer that spreads. Most cases of VIN, though, never lead to cancer.

Other possible risk factors may include:

  • History of abnormal Pap smears
  • Having many sexual partners
  • Having first sexual intercourse at 16 or younger

What are the symptoms for Vulvar Cancer?

Women with this condition will often have itching around the vagina for years. They may have used different skin creams. They may also have bleeding or discharge outside their periods.

Other skin changes that may occur around the vulva:

  • Mole or freckle, which may be pink, red, white, or gray
  • Skin thickening or lump
  • Skin sore (ulcer)

Other symptoms:

  • Pain or burning with urination
  • Pain with intercourse
  • Unusual odor

Some women with vulvar cancer have no symptoms.

What are the current treatments for Vulvar Cancer?

Treatment involves surgery to remove the cancer cells. If the tumor is large (more than 2 cm) or has grown deeply into the skin, the lymph nodes in the groin area may also be removed.

Radiation, with or without chemotherapy, may be used to treat:

  • Advanced tumors that cannot be treated with surgery
  • Vulvar cancer that comes back

What are the support groups for Vulvar Cancer?

You can ease the stress of illness by joining a cancer support group. Sharing with others who have common experiences and problems can help you not feel alone.

What is the outlook (prognosis) for Vulvar Cancer?

Most women with vulvar cancer who are diagnosed and treated at an early stage do well. But a woman's outcome depends on:

  • The size of the tumor
  • The type of vulvar cancer
  • Whether the cancer has spread

The cancer commonly comes back at or near the site of the original tumor.

What are the possible complications for Vulvar Cancer?

Complications may include:

  • Spread of the cancer to other areas of the body
  • Side effects of radiation, surgery, or chemotherapy

When should I contact a medical professional for Vulvar Cancer?

Call your health care provider if you have any of these symptoms for more than 2 weeks:

  • Local irritation
  • Skin color change
  • Sore on the vulva

How do I prevent Vulvar Cancer?

Practicing safer sex may decrease your risk for vulvar cancer. This includes using condoms to protect against sexually transmitted infections (STIs).

A vaccine is available to protect against certain forms of HPV infection. The vaccine is approved to prevent cervical cancer and genital warts. It may help prevent other cancers linked to HPV, such as vulvar cancer. The vaccine is given to young girls before they become sexually active, and to adolescents and women up to age 45.

Routine pelvic exams can help detect vulvar cancer at an earlier stage. Earlier diagnosis improves your chances that treatment will be successful.

Female perineal anatomy

REFERENCES

Frumovitz M, Bodurka DC. Neoplastic diseases of the vulva: lichen sclerosus, intraepithelial neoplasia, paget disease, and carcinoma. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 30.

Jhingran A, Russell AH, Seiden MV, et al. Cancers of the cervix, vulva, and vagina. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 84.

Koh WJ, Greer BE, Abu-Rustum NR, et al. Vulvar cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017;15(1):92-120. PMID: 28040721 pubmed.ncbi.nlm.nih.gov/28040721/.

National Cancer Institute website. Vulvar cancer treatment (PDQ) - health professional version. www.cancer.gov/types/vulvar/hp/vulvar-treatment-pdq. Updated January 30, 2020. Accessed January 31, 2020.

  • Condition: Cancer of the Vulva
  • Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • Treatment Used: Surgery or Concurrent Radiation
  • Number of Patients: 0
  • Published —
This article discusses treatment for patients with cancer of the vulva.
  • Condition: Vulvar Myoma
  • Journal: Taiwanese journal of obstetrics & gynecology
  • Treatment Used: Cephalexin
  • Number of Patients: 1
  • Published —
This case report describes a patient with a vulvar myoma that was treated using oral cephalexin.
Clinical Trial
  • Status: Recruiting
  • Phase: Phase 1/Phase 2
  • Intervention Type: Drug, Biological
  • Participants: 180
  • Start Date: January 27, 2017
A Phase I/II Trial of T Cell Receptor Gene Therapy Targeting HPV-16 E7 for HPV-Associated Cancers
Clinical Trial
  • Status: Recruiting
  • Intervention Type: Biological
  • Participants: 30
  • Start Date: April 20, 2018
Far Eastern Memorial Hospital