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Last Updated: 01/07/2026

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Found 1701 publications

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Journal: Journal of molecular cell biology
Published: December 08, 2025

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Journal: Journal of diabetes investigation
Published: September 19, 2025

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.

Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.

Journal: Journal of medicinal chemistry
Published: September 18, 2025

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Journal: Cancer research
Published: August 06, 2025

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.

Journal: Cytogenetic and genome research
Published: July 07, 2025

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives.

Journal: Journal of medicinal chemistry
Published: June 17, 2025

High-throughput evaluation of novel WRN inhibitors.

High-throughput evaluation of novel WRN inhibitors.

Journal: SLAS discovery : advancing life sciences R & D
Published: June 09, 2025

Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging.

Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging.

Journal: European journal of medicinal chemistry
Published: June 08, 2025

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.

Targeting the Werner syndrome protein in microsatellite instability cancers: mechanisms and therapeutic potential.

Journal: Clinical and experimental medicine
Published: June 05, 2025

Synthetic Lethality as Emerging Treatment for Cancer: An Example by Using the Werner Syndrome Helicase (WRN) Inhibitors.

Synthetic Lethality as Emerging Treatment for Cancer: An Example by Using the Werner Syndrome Helicase (WRN) Inhibitors.

Journal: ACS medicinal chemistry letters
Published: May 05, 2025

Targeting Werner Syndrome Helicase with Small Molecules in Mismatch Repair-Deficient Cancers.

Targeting Werner Syndrome Helicase with Small Molecules in Mismatch Repair-Deficient Cancers.

Journal: ACS medicinal chemistry letters
Published: May 02, 2025

Post-Translational Modifications of the Werner Syndrome Protein WRN.

Post-Translational Modifications of the Werner Syndrome Protein WRN.

Journal: Cytogenetic and genome research
Published: April 20, 2025
Showing 1-12 of 1,701

Last Updated: 01/07/2026