Werner Syndrome Latest Advances

Ocular Manifestations in Patients with Werner Syndrome.

Journal: International journal of molecular sciences

Published: March 05, 2026

Targeting WRN helicase in MSI-H tumors: Synthetic lethality, small molecule discovery, and therapeutic perspectives.

Journal: European journal of medicinal chemistry

Published: February 11, 2026

The Werner syndrome RECQ helicase as a therapeutic target: new insights.

Journal: Expert opinion on therapeutic targets

Published: January 20, 2026

Discovery of WRN helicase inhibitors by 3D-CNN docking and ML consensus from traditional Chinese medicine monomers.

Journal: Journal of molecular graphics & modelling

Published: December 31, 2025

Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK Properties.

Journal: ACS medicinal chemistry letters

Published: December 31, 2025

Novel Werner Syndrome RecQ DNA Helicase (WRN) Inhibitors for Cancer Treatment.

Journal: ACS medicinal chemistry letters

Published: December 12, 2025

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Journal: Journal of molecular cell biology

Published: December 08, 2025

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Journal: Journal of diabetes investigation

Published: September 19, 2025

Preferential correction of target genes by 5'-tailed duplexes with an antisense editor strand.

Journal: Journal of bioscience and bioengineering

Published: September 16, 2025

Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.

Journal: Communications biology

Published: August 09, 2025

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Journal: Cancer research

Published: August 06, 2025

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.

Journal: Cytogenetic and genome research

Published: July 07, 2025

Werner Syndrome Latest Advances

Find the Latest Research About Werner Syndrome

Ocular Manifestations in Patients with Werner Syndrome.

Ocular Manifestations in Patients with Werner Syndrome.

Targeting WRN helicase in MSI-H tumors: Synthetic lethality, small molecule discovery, and therapeutic perspectives.

Targeting WRN helicase in MSI-H tumors: Synthetic lethality, small molecule discovery, and therapeutic perspectives.

The Werner syndrome RECQ helicase as a therapeutic target: new insights.

The Werner syndrome RECQ helicase as a therapeutic target: new insights.

Discovery of WRN helicase inhibitors by 3D-CNN docking and ML consensus from traditional Chinese medicine monomers.

Discovery of WRN helicase inhibitors by 3D-CNN docking and ML consensus from traditional Chinese medicine monomers.

Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK Properties.

Discovery and Preclinical Evaluations of Potent, Selective, and Allosteric Covalent WRN Inhibitors with Improved PK Properties.

Novel Werner Syndrome RecQ DNA Helicase (WRN) Inhibitors for Cancer Treatment.

Novel Werner Syndrome RecQ DNA Helicase (WRN) Inhibitors for Cancer Treatment.

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Tumorigenic p53N236S balances aging and tumorigenesis via regulating DREAM/MMB and downstream telomere DNA replication pathways.

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.

Preferential correction of target genes by 5'-tailed duplexes with an antisense editor strand.

Preferential correction of target genes by 5'-tailed duplexes with an antisense editor strand.

Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.

Structural insights into WRN helicase reveal conformational states and opportunities for MSI-H cancer drug discovery.

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Editor's Note: Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway.

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.

Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network.