West SyndromeSymptoms, Doctors, Treatments, Advances & More
West Syndrome Overview
Learn About West Syndrome
- West syndrome
- IS
- Infantile spasm
- Tonic spasms with clustering, arrest of psychomotor development and hypsarrhythmia on EEG
- West's syndrome
- X-linked infantile spasm syndrome
- X-linked infantile spasms
Montefiore Medical Center
The maturation of GABAA receptor-mediated signaling from depolarizing to inhibitory is an age-related process controlled by cation chloride cotransporters, such as KCC2. As a result, GABA exerts dual functions, being an important neurotrophic factor during early development and the principal inhibitory neurotransmitter of the mature central nervous system. In our laboratory we have been investigating the age and mechanisms through which early life stressors and seizures may disrupt the normal patterns of brain development, by disrupting the neurotrophic effects of GABA. We are also studying methods to reverse these adverse processes. Furthermore, we are very interested in understanding how epileptogenesis proceeds in the developing brain and what is the specific role of GABAA receptors in this process. Dr. Galanopoulou is rated as an Elite provider by MediFind in the treatment of West Syndrome. She is also highly rated in 9 other conditions, according to our data. Her clinical expertise encompasses West Syndrome, Spasmus Nutans, Post-Traumatic Epilepsy, and Epilepsy.
The Children's Hospital At Montefiore
Solomon L. Moshé, MD, is Vice Chair of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology at Montefiore. He is also the Charles Frost Chair in Neurosurgery and Neurology, Vice Chair, Saul R. Korey Department of Neurology, and Professor of Neurology, Neuroscience and Pediatrics at the Albert Einstein College of Medicine (Einstein). Dr. Moshé’s clinical focus is on epilepsy and electroencephalography with special emphasis on age-related influences on the expression, control and consequences of seizures. Dr. Moshe is rated as an Elite provider by MediFind in the treatment of West Syndrome. He is also highly rated in 14 other conditions, according to our data. His clinical expertise encompasses West Syndrome, Spasmus Nutans, Post-Traumatic Epilepsy, and Epilepsy.
Cleveland Clinic Main Campus
Elia Knight is a Pediatrics provider practicing medicine in Cleveland, Ohio. Dr. Knight is rated as an Elite provider by MediFind in the treatment of West Syndrome. She is also highly rated in 107 other conditions, according to our data. Her clinical expertise encompasses CDKL5 Deficiency Disorder, West Syndrome, Seizures, and Epilepsy. Dr. Knight is board certified in American Board Of Psychiatry And Neurology, 2013.
Summary: This is a phase II clinical trial in which children with refractory infantile spasms (also called epileptic spasms or West syndrome) will be treated with fenfluramine, to evaluate efficacy, safety, and tolerability. Patients with infantile spasms that have not responded to treatment with vigabatrin and ACTH we will be invited to participate. Study participants will undergo baseline video-EEG, rece...
Summary: Rare epilepsies as a whole account for 20-30% of epilepsies, but knowledge about prognostic factors is currently limited. This means that it is difficult to provide adequate information to families at diagnosis and during follow-up. Prognostic factors are also important for management as they can have an impact on the patient's outcome (time to intervention, choice of one molecule over another, et...
Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center


