The maturation of GABAA receptor-mediated signaling from depolarizing to inhibitory is an age-related process controlled by cation chloride cotransporters, such as KCC2. As a result, GABA exerts dual functions, being an important neurotrophic factor during early development and the principal inhibitory neurotransmitter of the mature central nervous system. In our laboratory we have been investigating the age and mechanisms through which early life stressors and seizures may disrupt the normal patterns of brain development, by disrupting the neurotrophic effects of GABA. We are also studying methods to reverse these adverse processes. Furthermore, we are very interested in understanding how epileptogenesis proceeds in the developing brain and what is the specific role of GABAA receptors in this process. Dr. Galanopoulou is rated as an Elite provider by MediFind in the treatment of West Syndrome. Her top areas of expertise are West Syndrome, Spasmus Nutans, Post-Traumatic Epilepsy, and Epilepsy.

Solomon L. Moshé, MD, is Vice Chair of Neurology, Director of the Isabelle Rapin Child Neurology Division and Director of Clinical Neurophysiology at Montefiore. He is also the Charles Frost Chair in Neurosurgery and Neurology, Vice Chair, Saul R. Korey Department of Neurology, and Professor of Neurology, Neuroscience and Pediatrics at the Albert Einstein College of Medicine (Einstein). Dr. Moshé’s clinical focus is on epilepsy and electroencephalography with special emphasis on age-related influences on the expression, control and consequences of seizures. Dr. Moshe is rated as an Elite provider by MediFind in the treatment of West Syndrome. His top areas of expertise are West Syndrome, Spasmus Nutans, Post-Traumatic Epilepsy, and Epilepsy.

Elia Knight is a Pediatrics provider in Cleveland, Ohio. Dr. Knight is rated as an Elite provider by MediFind in the treatment of West Syndrome. Her top areas of expertise are CDKL5 Deficiency Disorder, West Syndrome, Seizures, and Epilepsy.