Condition 101 About West Syndrome

What is the definition of West Syndrome?

West syndrome is characterized by a specific type of seizure (infantile spasms) seen in infancy and childhood. This syndrome leads to developmental regression and causes a specific pattern, known as hypsarrhythmia (chaotic brain waves), on electroencephalography (EEG) testing. The infantile spasms usually begin in the first year of life, typically between 4-8 months. The seizures primarily consist of a sudden bending forward of the body with stiffening of the arms and legs; some children arch their backs as they extend their arms and legs. Spasms tend to occur upon awakening or after feeding, and often occur in clusters of up to 100 spasms at a time. Infants may have dozens of clusters and several hundred spasms per day. Infantile spasms usually stop by age five, but may be replaced by other types of seizures. Many disorders leading to brain injury, such as birth problems, cerebral anomalies, metabolic disorders, and genetic disorders can lead to these spasms, making it important to identify the underlying cause. In some children, no cause can be found. The goals of treatment are to reduce or eliminate seizures, and include several medications, such as corticoids, avigabatrin, and antiepileptic drugs. Some children have spasms as the result of brain lesions, and surgical removal of these lesions may result in improvement.

What are the alternative names for West Syndrome?

  • Infantile spasm
  • IS
  • X-linked infantile spasm syndrome
  • X-linked infantile spasms
  • West's syndrome
  • Tonic spasms with clustering, arrest of psychomotor development and hypsarrhythmia on EEG

Latest Advances On West Syndrome

  • Condition: Prostate Cancer
  • Journal: Lancet (London, England)
  • Treatment Used: Transdermal Estradiol
  • Number of Patients: 1694
  • Published —
This study tested the safety and efficacy of using transdermal estradiol for prevention of androgen toxicity in patients with prostate cancer.
  • Condition: Fever with Osteomyelitis (Serotonin Syndrome)
  • Journal: BMJ case reports
  • Treatment Used: Pregabalin and Tapentadol with Amitriptyline and Sertraline
  • Number of Patients: 1
  • Published —
This case report describes a patient with fever and osteomyelitis, a possible diagnosis of serotonin syndrome.

Clinical Trials For West Syndrome

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 1
  • Intervention Type: Drug
  • Participants: 10
  • Start Date: April 2021
A Phase I Open-Label Pilot Study to Investigate the Feasibility, Safety, Tolerability and Efficacy of Daily Administration of Tricaprilin in Subjects With Infantile Spasms
Clinical Trial
  • Status: Recruiting
  • Participants: 250
  • Start Date: November 13, 2020
KArukera Study of Ageing in Foster Families