Learn About White Sponge Nevus
White sponge nevus is a condition characterized by the formation of white patches of tissue called nevi (singular: nevus) that appear as thickened, velvety, sponge-like tissue. The nevi are most commonly found on the moist lining of the mouth (oral mucosa), especially on the inside of the cheeks (buccal mucosa). Affected individuals usually develop multiple nevi. Rarely, white sponge nevi also occur on the mucosae (singular: mucosa) of the nose, esophagus, genitals, or anus. The nevi are caused by a noncancerous (benign) overgrowth of cells.
Mutations in the KRT4 or KRT13 gene cause white sponge nevus. These genes provide instructions for making proteins called keratins. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body and make up the different mucosae. The keratin 4 protein (produced from the KRT4 gene) and the keratin 13 protein (produced from the KRT13 gene) partner together to form molecules known as intermediate filaments. These filaments assemble into networks that provide strength and resilience to the different mucosae. Networks of intermediate filaments protect the mucosae from being damaged by friction or other everyday physical stresses.
The exact prevalence of white sponge nevus is unknown, but it is estimated to affect less than 1 in 200,000 individuals worldwide.
This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell can be sufficient to cause the disorder. However, some people who have a mutation that causes white sponge nevus do not develop these abnormal growths; this phenomenon is called reduced penetrance.
Wenping Cai practices in Shanghai, China. Cai is rated as an Elite expert by MediFind in the treatment of White Sponge Nevus. Their top areas of expertise are White Sponge Nevus, Infective Endocarditis, Adenoid Cystic Carcinoma, and Brain Aneurysm.
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Adrienne Laury, MD, is a board-certified otolaryngologist who manages a wide range of adult and pediatric disorders of the ear, nose and throat. She is also a fellow of the American Academy of Otolaryngic Allergy and treats patients with environmental and food allergies. Dr. Laury has a particular interest and significant research experience in the medical and surgical management of sleep disorders, sinonasal diseases, as well as sinus/barometric pressure headaches.Dr. Laury originally grew up in Allentown, Pennsylvania. She attended Villanova University where she graduated summa cum laude. She received her medical degree from the University of Pennsylvania Perelman School of Medicine and then completed her residency training at Emory University in Atlanta, Georgia. Dr. Laury then served as an Otolaryngologist in the United States Air Force for four years. While stationed in San Antonio, Texas, Maj. Laury was an Assistant Professor of Otolaryngology and instructed numerous residents and medical students. She also served a tour in Afghanistan where she managed facial trauma injuries for deployed American troops.Dr. Laury has received numerous distinctions in teaching and brings that excellence in education to her patients. She is also a nationally recognized lecturer on allergy and sinus headache. Additionally, her extensive research endeavors have enabled her to utilize the most current techniques to care for her patients.Dr. Laury is married and has two young boys and a baby girl. Her husband, originally from Germany, works in software development for Amazon. Dr. Laury enjoys cooking, cycling, traveling, and her guilty pleasure - reality TV. Dr. Laury is rated as an Experienced provider by MediFind in the treatment of White Sponge Nevus. Her top areas of expertise are Chronic Rhinosinusitis with Nasal Polyps (CRSwNP), Sinusitis, Nasal Polyps, and Empyema.
Ari Goldsmith is a Pediatric Otolaryngologist and an Otolaryngologist in Brooklyn, New York. Dr. Goldsmith is rated as an Advanced provider by MediFind in the treatment of White Sponge Nevus. His top areas of expertise are White Sponge Nevus, Laryngomalacia, Tongue Tie, and Familial Deafness.
Published Date: February 01, 2014
Published By: National Institutes of Health