Learn About X-Linked Dystonia-Parkinsonism

What is the definition of X-Linked Dystonia-Parkinsonism?

X-linked dystonia-parkinsonism is a movement disorder that has been found only in people of Filipino descent. This condition affects men much more often than women.

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What are the causes of X-Linked Dystonia-Parkinsonism?

Mutations in and near the TAF1 gene can cause X-linked dystonia-parkinsonism. The TAF1 gene provides instructions for making part of a protein called transcription factor IID (TFIID). This protein is active in cells and tissues throughout the body, where it plays an essential role in regulating the activity of most genes.

How prevalent is X-Linked Dystonia-Parkinsonism?

X-linked dystonia-parkinsonism has been reported in more than 500 people of Filipino descent, although it is likely that many more Filipinos are affected. Most people with this condition can trace their mother's ancestry to the island of Panay in the Philippines. The prevalence of the disorder is 5.24 per 100,000 people on the island of Panay.

Is X-Linked Dystonia-Parkinsonism an inherited disorder?

This condition is inherited in an X-linked recessive pattern. The gene associated with this condition is located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation typically must occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, males are affected by X-linked recessive disorders much more frequently than females. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.

Who are the top X-Linked Dystonia-Parkinsonism Local Doctors?
Elite
Highly rated in
14
conditions
Neurology

Brigham Health

Neurology Associates

165 Cambridge St 
Boston, MA 2114

Nutan Sharma is a Neurologist in Boston, Massachusetts. Dr. Sharma has been practicing medicine for over 27 years and is rated as an Elite doctor by MediFind in the treatment of X-Linked Dystonia-Parkinsonism. She is also highly rated in 14 other conditions, according to our data. Her top areas of expertise are Drug Induced Dyskinesia, Focal Dystonia, X-Linked Dystonia-Parkinsonism, and Dopa-Responsive Dystonia. She is licensed to treat patients in Massachusetts. Dr. Sharma is currently accepting new patients.

Distinguished
Highly rated in
21
conditions
Neurology

Cedars-Sinai Health System

Cedars-Sinai Pituitary Center

127 S San Vicente Blvd 
Los Angeles, CA 90048

Michele Tagliati is a Neurologist in Los Angeles, California. Dr. Tagliati has been practicing medicine for over 36 years and is rated as a Distinguished doctor by MediFind in the treatment of X-Linked Dystonia-Parkinsonism. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are Parkinson's Disease, Drug Induced Dyskinesia, X-Linked Dystonia-Parkinsonism, and Focal Dystonia. He is licensed to treat patients in New York. Dr. Tagliati is currently accepting new patients.

 
 
 
 
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Distinguished
Highly rated in
11
conditions
Neurology

Mount Sinai Health System

Mount Sinai Union Square

10 Union Square E 
New York, NY 10003

Susan Bressman is a Neurologist in New York, New York. Dr. Bressman has been practicing medicine for over 45 years and is rated as a Distinguished doctor by MediFind in the treatment of X-Linked Dystonia-Parkinsonism. She is also highly rated in 11 other conditions, according to our data. Her top areas of expertise are Parkinson's Disease, Drug Induced Dyskinesia, Focal Dystonia, and X-Linked Dystonia-Parkinsonism. She is licensed to treat patients in New York.

What are the latest X-Linked Dystonia-Parkinsonism Clinical Trials?
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin for the Treatment of Muscle Spasm Associated With Neurological Disorders
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Who are the sources who wrote this article ?

Published Date: December 01, 2008Published By: National Institutes of Health

What are the Latest Advances for X-Linked Dystonia-Parkinsonism?
A case suspected of dystonia with marked cerebellar atrophy with torsion dystonia of the neck and cerebellar ataxia that developed during pharmacologic schizophrenia treatment.
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