Learn About X-Linked Ichthyosis

What is the definition of X-Linked Ichthyosis?
X-linked ichthyosis is a disorder in which the skin cells are produced at a normal rate but they do not separate properly at the surface of the stratum corneum (the outermost layer of the skin). This slows the rate of shedding of the skin cells, resulting in a build-up of scales. The scales of X-linked ichthyosis are often dark and usually cover only a portion of the body. Typically, the trunk and back of the neck are more likely to be affected. Scales are usually not found on the face, scalp, palms of the hands, and soles of the feet. X-linked ichthyosis mostly affects males. It is usually caused by a mutation or deletion in the STS gene and is inherited in an X-linked recessive manner. In rare cases, the ichthyosis can be part of a genetic syndrome in which other parts of the body are affected. Topical treatment may consist of alpha-hydroxy acids, lubricating bath oils, and emollients. For adult patients, systemic retinoids may be an option, especially during winter when the ichthyosis is often more severe. The ichthyosis is life-long, but the scaling may improve with age.
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What are the alternative names for X-Linked Ichthyosis?
  • Steroid sulfatase deficiency
  • SSD
  • SSDD
  • Steroid sulfatase deficiency disease
  • Placental steroid sulfatase deficiency
  • X linked ichthyosis
Who are the top X-Linked Ichthyosis Local Doctors?
Elite
Highly rated in
1
conditions

Justus Liebig University

Giessen, HE, DE 

Alberto Guijo-Sanchez is in Giessen, Germany. Guijo-Sanchez is rated as an Elite expert by MediFind in the treatment of X-Linked Ichthyosis. He is also highly rated in 1 other condition, according to our data. His top areas of expertise are X-Linked Ichthyosis, Apparent Mineralocorticoid Excess, Intraductal Papilloma, and Cushing Syndrome.

Distinguished
Highly rated in
17
conditions

Justus Liebig University

Giessen, HE, DE 

Stefan Wudy is in Giessen, Germany. Wudy is rated as a Distinguished expert by MediFind in the treatment of X-Linked Ichthyosis. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are Congenital Adrenal Hyperplasia, Intersex, X-Linked Ichthyosis, and Male Pseudohermaphroditism with Gynecomastia.

 
 
 
 
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Distinguished
Highly rated in
17
conditions

University Of Münster

Muenster, NW, DE 

Heiko Traupe is in Muenster, Germany. Traupe is rated as a Distinguished expert by MediFind in the treatment of X-Linked Ichthyosis. He is also highly rated in 17 other conditions, according to our data. His top areas of expertise are X-Linked Ichthyosis, Nonbullous Congenital Ichthyosiform Erythroderma, Lamellar Ichthyosis, and Ichthyosis Vulgaris.

What are the latest X-Linked Ichthyosis Clinical Trials?
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What are the Latest Advances for X-Linked Ichthyosis?
Steroid sulfatase deficiency causes cellular senescence and abnormal differentiation by inducing Yippee-like 3 expression in human keratinocytes.
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