Overview
Fyza Shaikh is an Assistant Professor in Cancer Immunology in the Department of Oncology in the Sidney Kimmel Comprehensive Cancer Center. She joined the faculty after completing her fellowship in medical oncology at Johns Hopkins School of Medicine (JHSOM) and residency in internal medicine at the University of Pittsburgh Medical Center as part of the ABIM research pathway. She received her MD and PhD in Microbiology and Immunology at Vanderbilt University School of Medicine. The Shaikh lab at JHSOM is focused on how the microbiome impacts host immunological responses to tumorigenesis and anti-tumor responses to immunomodulatory agents. The lab uses a combination of translational approaches using samples collected from human cohort studies and clinical trials as well as murine models to ask more detailed mechanistic questions and works across multiple tumor types (melanoma, lung, esophageal, head and neck, etc). The overall approach uses combination of clinical, computational, and lab-based techniques using a rich biorepository containing clinically annotated metadata with known and putative biomarkers of ICI response, such as PD-L1 and tumor mutational burden, paired with longitudinal fecal and plasma samples that correlate with clinical milestones (i.e. response/nonresponse by imaging and treatment-related toxicity). The goal is to focus on microbial functionality and build defined bacterial consortia that can then be tested in murine models to define colonization, metabolomics, and intra-tumoral immune response. This translational approach, with cross-sectional and longitudinal analysis of human samples, paired with mechanistic studies in murine models, has the potential to address both limitations in previously published studies and generate new hypotheses to make advances in this field and improve ICI responses for patients with advanced malignancies.
Her top areas of expertise are Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), Melanoma, and Esophageal Cancer.
Her clinical research consists of co-authoring 17 peer reviewed articles. MediFind looks at clinical research from the past 15 years.
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Locations
Baltimore, MD 21287
Clinical Research
Clinical research consists of overseeing clinical studies of patients undergoing new treatments and therapies, and publishing articles in peer reviewed medical journals. Providers who actively participate in clinical research are generally at the forefront of the fields and aware of the most up-to-date advances in treatments for their patients.
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Dr. Matthias Holdhoff is a medical oncologist and co-director of the Brain Cancer Disease Group at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He is a professor of oncology, neurology and neurological surgery at Johns Hopkins University School of Medicine. Dr. Holdhoff’s expertise is in primary brain cancers and central nervous system lymphomas. He earned his medical degree from Freie Universität Berlin, received his doctorate degree at Charité University Medicine Berlin. Dr. Holdhoff completed residency training in internal medicine at Johns Hopkins Bayview Medical Center, followed by a fellowship in medical oncology at Johns Hopkins Hospital with research training at the Ludwig Center for Cancer Genetics and Therapeutics (Kinzler-Vogelstein lab). As a clinical investigator in neuro-oncology, his research is focused on novel trials and translational biomarker studies in malignant gliomas and primary central nervous system lymphomas. He has led and contributed to numerous clinical trials, publications and presentations. Dr. Holdhoff serves as the director of the solid tumor inpatient service at the Sidney Kimmel Comprehensive Cancer Center. He is passionately involved in mentoring and teaching of fellows, residents and students. He is the director of the UCNS-certified neuro-oncology fellowship program at Johns Hopkins, and he is a teaching attending physician for the Osler internal medicine residency program. Dr. Holdhoff is highly rated in 19 conditions, according to our data. His top areas of expertise are Glioma, Glioblastoma, Astrocytoma, and Brain Tumor.
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Stuart Grossman, M.D., is a professor of oncology at the Johns Hopkins Kimmel Cancer Center. He has served as Principal Investigator and Director of the Central Operations office of the National Cancer Institute-funded phase I/II brain tumor consortia (New Approaches to Brain Tumor Therapy CNS Consortium and the Adult Brain Tumor Consortium) for the past 22 years. He has led many phase I, II, and III institutional and cooperative group translational and clinical brain cancer research projects. Dr. Grossman's expertise is in brain cancers, translational and clinical research, and directing large, multicenter, multidisciplinary clinical trial groups and training programs. Dr. Grossman was an intern and resident at Strong Memorial Hospital in Rochester, NY, and a fellow at the Johns Hopkins University School of Medicine. He received his M.D. from the University of Rochester. Dr. Grossman is highly rated in 16 conditions, according to our data. His top areas of expertise are Astrocytoma, Glioblastoma, Glioma, and Gliomatosis Cerebri.
Office
Taofeek Owonikoko is a Hematologist and an Oncologist in Baltimore, Maryland. Dr. Owonikoko is highly rated in 18 conditions, according to our data. His top areas of expertise are Small Cell Lung Cancer (SCLC), Lung Cancer, Non-Small Cell Lung Cancer (NSCLC), EGFR Positive Lung Cancer, and Tissue Biopsy.
Areas of Expertise
MediFind evaluates expertise by pulling from factors such as number of articles a doctor has published in medical journals, participation in clinical trials, speaking at industry conferences, prescribing and referral patterns, and strength of connections with other experts in their field.
Learn more about MediFind’s expert tiers
- Experienced
- Esophageal CancerDr. Shaikh isExperienced. Learn about Esophageal Cancer.
- Gallbladder AdenocarcinomaDr. Shaikh isExperienced. Learn about Gallbladder Adenocarcinoma.
- Gallbladder CancerDr. Shaikh isExperienced. Learn about Gallbladder Cancer.
- Lung CancerDr. Shaikh isExperienced. Learn about Lung Cancer.
- MelanomaDr. Shaikh isExperienced. Learn about Melanoma.
- Non-Small Cell Lung Cancer (NSCLC)Dr. Shaikh isExperienced. Learn about Non-Small Cell Lung Cancer (NSCLC).