• Had been treated with Radical resection (D2, R0) of gastric cancer (Lymph node≥16);

• Physical condition and organ function allows to tolerable abdominal surgery;

• Willing and able to comply with the program during the study period;

• Written informed consent provided;

• ≥ 18 and ≤ 70 years of age; preoperative gastric cancer patients with pathologically confirmed;

• With more than a 6-month life expectancy;

• No other serious concomitant diseases; Sufficient organ functions;

• No previous history of chemotherapy or radiotherapy;

• All patients accept 8 cycles XELOX chemotherapy regimen;

⁃ Clinical stage: T2-4aN0-+M0;

⁃ Macroscopic types :Borrmann I-III;

⁃ Not greater curvature tumor;

⁃ No previous surgery for any abdominal disease, except an appendectomy for appendicitis, a laparoscopic cholecystectomy for gallbladder stones; No previous history of peritonitis, pancreatitis;

⁃ Karnofsky performance status (KPS)\>60; Eastern Cooperative Oncology Group Performance Status (ECOG): 0-1.