Comparison of Laparoscopic Versus Open Total Gastrectomy for Locally Advanced Gastric Cancer: a Prospective Randomized Control Trial

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Evidence of implementation of laparoscopic total gastrectomy (LTG) for locally advanced gastric cancer (GC) remains inadequate. This study aimed to compare short- and mid-term outcomes of LTG versus open total gastrectomy (OTG) for cT2-4a GC.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Pathologic finding by gastric endoscopy: confirmed gastric adenocarcinoma

• Age: 18 - 80 year old

• Tumor required total gastrectomy for radical treatment

• Preoperative cancer stage (CT scan stage): cT2-4aNanyM0

• ASA score: ≤ 3

• Informed consent patients (explanation about our clinical trials is provided to the patients or patrons, if patient is not available)

Locations
Other Locations
Viet Nam
Dong Nai General Hospital
RECRUITING
Biên Hòa
108 Military Central Hospital
NOT_YET_RECRUITING
Hà Nội
University Medical Center Ho Chi Minh City
RECRUITING
Ho Chi Minh City
Time Frame
Start Date: 2024-08-02
Estimated Completion Date: 2032-08-02
Participants
Target number of participants: 210
Treatments
Experimental: Laparoscopic total gastrectomy
5 trocars were used. The gastrocolic ligament was divided along the border of the transverse colon. ligating the left gastroepiploic vessels to remove group 4sb.~The right gastroepiploic vein was divided and right gastroepiploic and inferior pyloric artery were transected at their origin from the gastroduodenal artery to dissect group 6.~The dissection was continued along the hepatoduodenal ligament to removed group 5 and group 12a and along the common hepatic artery to remove group 8a and along the celiac axis to remove group 9.~The left gastric vein was divided and then the left gastric artery was vascularized to remove group 7.~The dissection was continued upward along the splenic artery and its branches to remove group 11p,d and/or along the splenic hilum to remove group 10.~The dissection was then conducted the right and left of the esophago-gastric junction to remove group 1,2.~As a general rule, Roux en Y method was used for esophagoo-jejunal reconstruction for all cases
Active_comparator: Open total gastrectomy
An incision of 15\~20 cm length is made in the abdominal midline . Standard total gastrectomy and omentectomy will be performed with D2 lymph node dissection (around common hepatic artery, celiac artery, along splenic artery, proper hepatic artery, and/or the splenic hilum) . Roux-en Y esophagojejunal anastomosis is performed for reconstruction.
Related Therapeutic Areas
Sponsors
Leads: University Medical Center Ho Chi Minh City (UMC)

This content was sourced from clinicaltrials.gov

Similar Clinical Trials