Effects of Total Gastrectomy or Double Track Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Observational
SUMMARY

Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 80
Healthy Volunteers: f
View:

• Clinical diagnosis of proximal gastric cancer and will be performed gastrectomy

• American Society of Anesthesiologists (ASA) classification I-III

• Aged 40-80 years

• Perioperative consciousness

Locations
Other Locations
China
Tongji Hospital
RECRUITING
Wuhan
Contact Information
Primary
Jiangjiang Bi, MD
bessie8210@163.com
862783665431
Time Frame
Start Date: 2024-01-20
Estimated Completion Date: 2026-06
Participants
Target number of participants: 45
Treatments
Probiotics (PR)
Patients undergoing total gastrectomy take probiotics qd for 3 months after surgery.
Total gastrectomy (TG)
Patients undergoing total gastrectomy
Double-tract reconstruction (DTR)
Patients undergoing double-tract reconstruction
Related Therapeutic Areas
Sponsors
Leads: Jiangjiang Bi

This content was sourced from clinicaltrials.gov