Zynrelef vs Exparel: The Battle of Postoperative Pain Control After Robotic Sleeve Gastrectomy

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The purpose of this study is to evaluate the use of an injectable combination of bupivacaine and meloxicam (Zynrelef) vs injectable liposomal bupivacaine (Exparel), two extended local anesthesia strategies currently approved by FDA and on the market for post-surgical pain control. The investigators plan on randomizing study participants to either Exparel or Zynrelef at the closure site of robotic sleeve gastrectomy and assessing their pain control postoperatively both in the hospital and at home. The investigators will measure the outcome of two drugs, Zynrelief, and Exparel on postoperative pain score -using the NRS pin score up to 72 hours after surgery. The total opioid use will be recorded in forms that will be used to measure pain score and total opioid use and will be collected to the Excel sheet. The cost of the drug will be calculated for internal use for Hospital purpose only.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:

• Age range: 18-65 years old

• Scheduled or being scheduled to undergo robotic sleeve gastrectomy by Dr. Goyal.

• Is able to provide written informed consent.

• Is able to adhere to the study visit schedule and complete all study assessments.

Locations
United States
Texas
Texas Tech University Health Sciences Center
RECRUITING
Lubbock
Contact Information
Primary
Tommy Wright, DO
tommy.wright@ttuhsc.edu
8176888021
Backup
Vinay Goyal, MD
vinay.goyal@ttuhsc.edu
Time Frame
Start Date: 2024-11-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 130
Treatments
Experimental: Patients who receive zynrelef
Those who get zynrelef injected at the at the 12mm port incision
Experimental: Patients who receive exparel
those who get exparel injected at the 12mm port incision
Sponsors
Leads: Texas Tech University Health Sciences Center

This content was sourced from clinicaltrials.gov