Effect of Colchicine on Coronary Reperfusion in Patients With Acute Coronary Syndrome
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
This randomized clinical trial will determine the treatment effect of colchicine (1.5 mg loading dose and 0.5 mg daily thereafter) for 6 weeks on microvascular coronary reperfusion and infarct size in patients with acute coronary syndrome.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years.
• Adults hospitalized at the Clinical Hospital of the Catholic University for an ACS condition, defined as:
• \- Presence of chest pain, associated with enzymatic elevation (increase of ultrasensitive troponin above normal value (99th percentile)) with or without electrocardiographic changes.
• Patients undergoing coronary angiography with the intention of angioplasty in the next few days (during the index hospitalization).
• Ability and willingness to provide written informed consent.
Locations
Other Locations
Chile
Hospital Clínico Pontificia Universidad Catolica de Chile
RECRUITING
Santiago
Contact Information
Primary
Gonzalo Martínez, MD
gmartinezr@med.puc.cl
56 223543218
Backup
Maria Paz Orellana
mporella@uc.cl
011 56 979683630
Time Frame
Start Date: 2022-08-01
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 50
Treatments
Experimental: Colchicine
Subjects allocated to the intervention group will receive colchicine + standard of care for 6 weeks.
No_intervention: Standard of Care - Control
Subjects allocated to the control group will receive only standard of care for 6 weeks.
Related Therapeutic Areas
Sponsors
Collaborators: Fondo Nacional de Desarrollo Científico y Tecnológico, Chile
Leads: Pontificia Universidad Catolica de Chile