Allogeneic γ9δ2 T Cells for the Treatment of Recurrent Hematologic Tumors After Allogeneic Hematopoietic Stem Cell Transplantation
This is an open single-arm clinical study aimed at evaluating the safety and tolerance of allogeneic γ9δ2 T cell injection in the treatment of patients with recurrent hematologic tumors after allogeneic hematopoietic stem cell transplantation.
• Age 12-65 (inclusive);
• Patients with recurrent hematologic tumors after allogeneic hematopoietic stem cell transplantation;
• Basically normal liver and kidney function (as demonstrated by the following laboratory tests prior to initial γ9δ2 T cell therapy)
‣ Alanine transaminase/aspartate transaminase \< 2.5×ULN;
⁃ serum creatinine \< 1.5×ULN;
⁃ total bilirubin level \< 1.5×ULN;
• No obvious hereditary disease;
• Normal cardiac function, cardiac ejection index above 55%;
• Women of reproductive age (15 to 49 years) must undergo a pregnancy test within 7 days before starting treatment and the result is negative, and use contraception during the clinical trial period and within 3 months after the last cell transfusion;
• Sign informed consent.