Cardiac Ablation Clinical Trials

Clinical trials related to Cardiac Ablation Procedure

ELectrocardiographic Imaging-guided Substrate Ablation in Patients With Atrial Fibrillation - a PILOT Study of a Personalized Therapy

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this pilot study is to test if noninvasive global mapping can guide catheter ablation defining personalized targets and improve the therapy of atrial fibrillation. It will also test the safety of such an approach. The main questions it aims to answer are: * Does ablation of targets defined by noninvasive global mapping improve rates of acute atrial fibrillation termination? * Does such a personalized ablation approach reduce arrhythmia recurrence rates? Researchers will compare the results of the personalized ablation approach with comparable patients that had undergone a conventional empirical ablation approach (pulmonary vein isolation). Participants will: * Undergo a personalized catheter ablation approach employing both a noninvasive global mapping system and a conventional intracardiac mapping system * Visit the clinic 3, 6 and 12 months after ablation for clinical follow-up * Schedule a telephone visit 9 and 24 months after ablation for clinical follow-up

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

⁃ Ablation-naïve patients with:

• Persistent AF planned for catheter ablation plus

• Left atrial enlargement (LA diameter ≥45 mm or LA volume index ≥35ml/m2 or LA area ≥20 cm2)

Locations
Other Locations
Spain
Hospital Clinic, University of Barcelona
RECRUITING
Barcelona
Contact Information
Primary
Till F Althoff, M.D.
till.althoff@dhzc-charite.de
+49 30 450513143
Backup
Ivo Roca-Luque, M.D., Ph.D.
iroca@clinic.cat
+34 93 2271778
Time Frame
Start Date: 2026-01-31
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 30
Treatments
Experimental: Non-invasive mapping-guided ablation
In this arm patients undergo a personalized ablation approach: In addition to conventional pulmonary vein isolation, additional target regions will be ablated based on non-invasive global mapping.
Related Therapeutic Areas
Sponsors
Leads: Hospital Clinic of Barcelona

This content was sourced from clinicaltrials.gov