Changes in Colonic Microbiome With Fiber Supplementation

Status: Recruiting
Location: See location...
Intervention Type: Procedure, Dietary supplement, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This clinical trial tests whether daily fiber supplementation will change the mucosal microbiome of the colon. The microbiome are microorganisms that live in the human gut. They serve a vital role in maintaining health. Certain microbial strains are associated with the growth of colon polyps, which eventually could go on to form colon cancer. Giving dietary fiber supplements may help prevent precancerous polyps from ever developing.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age \>= 18 years

• Ability to understand and the willingness to sign a written informed consent document

• Patients who present with a chief complaint of a benign anorectal pathology including hemorrhoids, anal fissures, and anal fistulas without underlying conditions such as colorectal cancer or Crohn's disease or are undergoing a standard of care colonoscopy procedure

Locations
United States
Oregon
OHSU Knight Cancer Institute
RECRUITING
Portland
Contact Information
Primary
Shahrose Rahman, M.D.
rahmasha@ohsu.edu
503-494-8652
Backup
Amber O'Connor
oconnoam@ohsu.edu
Time Frame
Start Date: 2023-04-01
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 120
Treatments
Experimental: Supportive care (oral fiber)
Patients receive dietary fiber orally (PO) on study. QD for 28 days. Patients may undergo standard of care proctoscopy or anoscopy with biopsy on study and duringat follow- up or may undergo standard of care colonoscopy on study. All patients also undergo collection of blood samples on study and at follow up.
Related Therapeutic Areas
Sponsors
Leads: OHSU Knight Cancer Institute

This content was sourced from clinicaltrials.gov