Determining the Impact of Dietary Intervention on Inflammation and Microbiome Composition in Patients With Recurrent Polyps Post-Colonoscopy.

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy. The investigators hypothesize that certain diets can positively influence gut bacteria, reducing inflammation and enhancing metabolic signals. To explore this, they will utilize metagenomic testing on stool samples to analyze the DNA of gut microorganisms. Additionally, they will conduct immune profiling on serum samples and perform metabolomic analysis to comprehensively evaluate the diet-induced changes in immune response and metabolic pathways. This multi-faceted approach will help them understand how dietary changes affect the composition and function of the gut microbiome, immune function, and overall metabolism.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• 1\. Due for 2nd or 3rd colonoscopy with prior diagnosis of tubular, villous, or serrated polyps but no current diagnosis of CRC.

Locations
United States
California
University of California, San Diego Altman Clinical and Translational Research Institute
RECRUITING
San Diego
Contact Information
Primary
Jack A Gilbert, PhD
jagilbert@health.ucsd.edu
858-246-5826
Backup
Sonia Ramamoorthy, MD
sramamoorthy@health.ucsd.edu
619-980-4625
Time Frame
Start Date: 2025-03-04
Estimated Completion Date: 2026-02
Participants
Target number of participants: 30
Treatments
Experimental: Dietary Intervention Group
Participants in this arm will follow a modified plant-based Mediterranean diet following their colonoscopies. The dietary intervention aims to reduce inflammation and improve gut microbiome composition. Participants' gut bacteria and overall health will be monitored through blood and stool sample collections, focusing on inflammation reduction and metabolic health improvement.
Related Therapeutic Areas
Sponsors
Collaborators: Seerave Foundation
Leads: University of California, San Diego

This content was sourced from clinicaltrials.gov