Summary: Patients that undergo decompressive craniectomy are at risk of delayed changes in brain function known as Sunken Flap Syndrome or Syndrome of the Trephined. The goal of this clinical trial is to see if placing a prosthetic over patients' skull defects can prevent Sunken Flap Syndrome. The main questions are: 1. Can placing a prosthetic device over patients' skull defects prevent Sunken Flap Syndro...

Summary: The objective of this trial is to scientifically evaluate the efficacy of PEEK cranioplasty and titanium cranioplasty. The primary objective is to compare the rate of implant failure (defined as infection, implant exposure and other causes requiring removal of the implanted material) at any time within 12 months after cranioplasty. The secondary objective is to compare the complication rates and n...

Summary: Intractable high intracranial pressures (ICP) are associated with poor functional outcomes and mortality, so the SCALPEL trials aims to evaluate the effect of decompressive craniectomy against decompressive laparotomy to lower those pressures in diffuse TBI. The primary outcome measure for that evaluation is functional outcome after 12 months on the extended Glasgow Outcome Scale (GOS-E).