Investigating Neural Biomarkers for Gait in Parkinson's Patients

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test, Other
Study Type: Observational
SUMMARY

This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options. Participants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
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⁃ All participants

• must have given informed consent as documented by signature

• agree to comply with the study procedures

⁃ Healthy control group

• no neurological, orthopedic, or rheumatologic disease history

• no identified sensory impairment.

• no epilepsy and self-diagnosed acute or chronic psychiatric disorders

⁃ Parkinson's Patients

• non-tremor dominant idiopathic PD patients

• presence of postural instability (UPDRS \>1 for postural instability \[17\]), gait disturbance, and absence of other causes of reduced balance

• Implanted with Percept™ PC neurostimulator

• Able to be in the stimulation OFF

Locations
Other Locations
Switzerland
Cereneo
RECRUITING
Vitznau
Contact Information
Primary
Lena Salzmann, MSc
lena.salzmann@hest.ethz.ch
+41788248679
Backup
Olivier Lambercy, PhD
oliver.lambercy@hest.ethz.ch
Time Frame
Start Date: 2023-04-13
Estimated Completion Date: 2025-03
Participants
Target number of participants: 60
Treatments
Young, healthy control
Young healthy participants below 45 years will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section.~During the protocol, neural activity is recorded using EEG.
Age-matched healthy control
Age-matched healthy participants above 45 years will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section.~During the protocol, neural activity is recorded using EEG.
Parkinson's patients
Parkinson's patients will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section. Additionally, a neuromodulation set-up will be tested.~During the protocol, neural activity is recorded using EEG and signals from the DBS-electrodes.
Related Therapeutic Areas
Deep Brain Stimulation
Movement Disorders
Parkinson's Disease
Sponsors
Leads: Swiss Federal Institute of Technology
Collaborators: cereneo center for Neurology and Rehabilitation, University of Zurich

This content was sourced from clinicaltrials.gov

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