• Group A

• Aged ≥30 years\* and able to give informed consent

• Patients attending colonoscopy

‣ Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance)

⁃ Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\*\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance)

∙ The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \*\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile

• (COLO-SPEED) Group B

• Any patient attending for colonoscopy and able to give informed consent

• ≥ 18 years old

• Patient from the North of England