Association Between Peri-procedural Intravenous Hydration and Post- Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

Aggressive intravenous hydration has been shown in randomized trials to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP), though studied regimens are often impractical. To date, no studies have prospectively assessed short-term (60-90 minute) aggressive hydration regimens that are feasible for outpatients undergoing ERCP and subsequent discharge. Furthermore, little is known with regard to fluid type, volume, and timing with respect to ERCP. In this study, we will aim to assess whether the amount of peri-procedural intravenous fluid administered around the time of ERCP is associated with the risk of PEP (the primary outcome).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:

• Subject referred for ERCP, regardless of indication;

• Subject age 18 years or older;

• Subject able to give informed consent to involvement be included.

Locations
Other Locations
Canada
Peter Lougheed Hospital
RECRUITING
Calgary
Contact Information
Primary
Nauzer Forbes, MD MSc
nauzer.forbes@ucalgary.ca
403-592-5089
Time Frame
Start Date: 2022-01-10
Estimated Completion Date: 2026-02-28
Participants
Target number of participants: 13000
Treatments
Aggressive hydration
Patients with greater than or equal to 2 L of intravenous crystalloid fluids administered within the immediate pre-, peri- and post-procedural period
Conservative hydration
Patients with less than 1 L of intravenous crystalloid fluids administered within the immediate pre-, peri- and post-procedural period
Related Therapeutic Areas
Sponsors
Collaborators: University of Ottawa, Queen's University, Halton Health (Oakville), McGill University, Island Health, Victoria, BC
Leads: University of Calgary

This content was sourced from clinicaltrials.gov