Effectiveness of an Optimisation Strategy for Emergency Tracheal Intubation on Postintubation Morbidity: A Cluster Randomized Controlled Trial
Status: Recruiting
Location: See all (22) locations...
Intervention Type: Procedure, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. This strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and Gum Elastic Bougie (GEB) use.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.
• Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.
Locations
Other Locations
France
CHU d'Angers
RECRUITING
Angers
CH Carnelle Portes de l'Oise
RECRUITING
Beaumont-sur-oise
AP-HP - Hôpital Avicenne
RECRUITING
Bobigny
CHU de Bordeaux - Hôpital Pellegrin
RECRUITING
Bordeaux
CH de Pontoise René Dubos
RECRUITING
Cergy-pontoise
AP-HP - Hôpital Henri Mondor
RECRUITING
Créteil
CHU de Dijon
NOT_YET_RECRUITING
Dijon
GH Eaubonne Montmorency Hôpital Simone VEIL
RECRUITING
Eaubonne
AP-HP - Hôpital Raymond Poincaré
RECRUITING
Garches
CHU de Grenoble - Hôpital Nord La Tronche
RECRUITING
La Tronche
CH de Versailles - Site André Mignot
NOT_YET_RECRUITING
Le Chesnay
HCL - Hôpital Edouard Herriot
RECRUITING
Lyon
GH Sud Ile de France
RECRUITING
Melun
CHU de Montpellier Site Lapeyronie
RECRUITING
Montpellier
CHU de Nantes - Hôpital Hôtel Dieu
RECRUITING
Nantes
AP-HP - Hôpital Lariboisière
RECRUITING
Paris
AP-HP - Hôpital Necker
RECRUITING
Paris
AP-HP - Hôpital Pitié-Salpétrière
RECRUITING
Paris
CHU Poitiers - Hôpital la Milétrie
RECRUITING
Poitiers
CHU de la Réunion - site Sud
RECRUITING
Saint-pierre
GH Sélestat Obernai
NOT_YET_RECRUITING
Sélestat
CHU Toulouse - Hôpital Purpan
RECRUITING
Toulouse
Contact Information
Primary
Xavier COMBES, Pr
xavier.combes@chu-bordeaux.fr
05 56 79 49 47
Time Frame
Start Date: 2023-01-14
Estimated Completion Date: 2026-09
Participants
Target number of participants: 1500
Treatments
Experimental: Treatment group
Combination rapid sequence intubation (RSI) with use of rocuronium and the bag-mask ventilation between induction and Gum Elastic Bougie GEB will be systematically used at the first attempt to facilitate intubation.
Active_comparator: Control Group
Physicians will be reminded of the current recommendations for emergency intubation: Rapid sequence intubation (RSI) using succinylcholine and use of GEB to facilitate intubation in case of intubation failure under direct laryngoscopy.
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Bordeaux