Preventing Recurrent 'Idiopathic' Acute Pancreatitis Through Laparoscopic Cholecystectomy (PICUS-2): a Multicenter Randomized Trial
Objective: To assess the effectiveness of LC as compared to conservative treatment in patients after a first, second or third episode of an 'EUS-negative' IAP. Study design: Multicenter randomized controlled trial. Patients will be followed for one year after randomization. Study population: Adults with a first, second or third episode of IAP, of which at least one episode is characterized by a 'negative EUS'. Intervention (if applicable): Laparoscopic cholecystectomy versus conservative treatment. Main study parameters/endpoints: The primary endpoint is pancreatitis recurrence. Secondary endpoints include occurrence of biliary events, complications of LC, number and severity of recurrent episodes of pancreatitis, quality of life (QALY), costs (hospital and societal) and cost-effectiveness.
• At least 18 years old
• Eligible for early (laparoscopic)\* cholecystectomy
• Full required diagnostic work-up of patient has been performed, including EUS
• First, second or third episode of IAP, of which at least one episode characterized by a 'negative-EUS'' result
• Informed consent for participation was obtained \*if required open cholecystectomy is allowed