A Multicenter, Prospective Study of Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

Status: Recruiting
Location: See all (12) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to evaluate the diagnostic accuracy of the AI-integrated Capsule Gastroscopy (ACG) system in simulated home-use conditions for detecting upper gastrointestinal (UGI) abnormalities. It will also compare the diagnostic accuracy and time efficiency of AI-assisted interpretation versus manual reading of ACG data. The main questions it aims to answer are: What is the diagnostic accuracy of the ACG system, using conventional esophagogastroduodenoscopy (EGD) as a standard of reference? Does AI-assisted ACG reading improve diagnostic accuracy or reduce reading time compared to manual ACG video reading? Researchers will compare ACG results to conventional EGD findings (standard of reference) to determine if ACG can serve as a reliable method for UGI disease detection in home scenarios. Participants will: Undergo an ACG examination in a simulated home environment. Complete an EGD procedure within 24 hours post-ACG ingestion.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Aged 18 years or older.

• Individuals meeting the following criteria:

• i. Healthy volunteers; ii. Suspected presence of gastrointestinal diseases, with one or more of the following clinical symptoms: abdominal pain, nausea, vomiting, hematemesis, black or bloody stools, loss of appetite, bloating, or indigestion; iii. Follow-up of gastric lesions post-endoscopic resection.

• Willing to participate voluntarily in the clinical trial and provide written informed consent.

• Capable of communicating with researchers and complying with trial requirements.

Locations
Other Locations
China
Ganzhou People's Hospital
RECRUITING
Ganzhou
Guangdong Provincial Hospital of Traditional Chinese Medicine
RECRUITING
Guangzhou
Nanfang Hospital, Southern Medical University
RECRUITING
Guangzhou
Second Affiliated Hospital of Guangzhou Medical University
RECRUITING
Guangzhou
Mianyang Central Hospital
RECRUITING
Mianyang
Renhua People's Hospital
RECRUITING
Shaoguan
Longgang District People's Hospital of Shenzhen
RECRUITING
Shenzhen
Pingshan People's Hospital
RECRUITING
Shenzhen
Wuxi People's Hospital.
RECRUITING
Wuxi
Zhuhai People's Hospital
RECRUITING
Zhuhai
Hong Kong Special Administrative Region
Prince of Wales Hospital of Hong Kong
RECRUITING
Hong Kong
Italy
Fondazione Poliambulanza Istituto Ospedaliero
NOT_YET_RECRUITING
Brescia
Contact Information
Primary
Xiaobei Luo
luoxiaobei63@126.com
+86 17688881428
Time Frame
Start Date: 2025-03-03
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 482
Treatments
Experimental: Testing Group
Product name: Gastric Capsule Endoscope System Specification model: GICE-1000 Manufacturer: Guangzhou Side Medical Technology Co., Ltd. Participants fast for at least 8 hours and take mucolytics and anti-foaming agents 30 minutes before the ACG. Following video instructions, they connect the capsule with mobile, activate the capsule, and swallow it with water. Participants remain blinded to real-time ACG video. Researchers observe and record whether the participants have completed the examination as instructed in the video and any adverse events (without guidance). Data will be uploaded post-exam via WiFi or the manufacturer's system. Capsule discharge will be tracked.
Active_comparator: Control group
Product name: Electronic gastrointestinal endoscope (EGD) Specifications and models: GIF-290 series Manufacturer: Olympus, Tokyo, Japan EGD was the reference standard against which ACG was compared, and it was performed within 24 hours post-ACG ingestion time. Participants will fast for at least 8 hours (clear water is allowed) and take mucolytics and anti-foaming agents 30 minutes before the EGD.~The EGD will then be performed by endoscopists with more than 500 EGD procedures completed, who are blinded to the ACG examination results. The procedure for this study will adhere to the Systematic Screening Protocol for the Stomach (SSS), as outlined by Yao et al(8).The endoscopists will record any lesions identified (including lesion type, location, size, number of lesions etc.), and biopsies or treatments will be performed following white-light EGD screening, if necessary. Anonymous reports, images, and videos will be exported for further analysis.
Sponsors
Collaborators: Prince of Wales Hospital, Shatin, Hong Kong, Ganzhou People's Hospital, Pingshan People's Hospital, Mianyang Central Hospital, Wuxi People's Hospital, Renhua People's Hospital, Longgang District People's Hospital of Shenzhen, Guangdong Provincial Hospital of Traditional Chinese Medicine, Fondazione Poliambulanza Istituto Ospedaliero, Second Affiliated Hospital of Guangzhou Medical University, ZhuHai Hospital
Leads: Nanfang Hospital, Southern Medical University

This content was sourced from clinicaltrials.gov