Small Bowel Capsule Endoscopy for (Pre)Neoplastic Lesion Screening in Patients With Lynch Syndrome
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
The impact of small bowel (SB) capsule endoscopy (CE) on the screening (followed by diagnosis and treatment) of (pre)neoplastic lesions of the small bowel in Lynch syndrome (LS) patients is unknown. The iCARE4Lynch study is a retrospective cohort of patients carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM) who had had at least one SBCE for screening of small bowel (pre)neoplastic lesions between January 1st 2000 and December 31 2024.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)
• Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine
• No opposition to the reuse of healthcare data for research purposes
Locations
Other Locations
France
Center for Digestive Endoscopy, Saint-Antoine Hospital
RECRUITING
Paris
Contact Information
Primary
Xavier DRAY, MD PhD
xavier.dray@aphp.fr
+33 (0) 1 49 28 21 61
Backup
Aymeric BECQ, MD
aymeric.becq@aphp.fr
+33 (0) 1 49 81 23 55
Time Frame
Start Date: 2025-06-16
Estimated Completion Date: 2026-12
Participants
Target number of participants: 400
Related Therapeutic Areas
Sponsors
Leads: Assistance Publique - Hôpitaux de Paris