Gallbladder Removal Clinical Trials

Clinical trials related to Gallbladder Removal Procedure

Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial

Status: Recruiting

Location: See location...

Intervention Type: Procedure, Drug

Study Type: Interventional

Study Phase: Not Applicable

SUMMARY

This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea/vomiting, mobilization time, and length of hospital stay.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Maximum Age: 65

Healthy Volunteers: f

View:

• Age between 18 and 65 years

• Scheduled for elective laparoscopic cholecystectomy under general anesthesia

• ASA physical status I-III

• Able to understand the study procedure and provide informed consent

Locations

Other Locations

Turkey

Cukurova University Faculty of Medicine

RECRUITING

Adana

Contact Information

Primary

Nurefsan Sadikoglu, MD

nurefsansadikoglu@gmail.com

+(90) 538 926 2414

Backup

Zehra Hatipoglu, MD

hatipogluzehra@gmail.com

+(90) 532 447 1670

Time Frame

Start Date: 2025-12-01

Estimated Completion Date: 2026-12-05

Participants

Target number of participants: 147

Treatments

Active_comparator: Paravertebral Block Group

Participants in this arm will receive bilateral paravertebral block after induction of general anesthesia. Under ultrasound guidance, 0.25% bupivacaine (20 mL per side; total 40 mL) will be administered to provide postoperative analgesia following laparoscopic cholecystectomy. Patients will also receive standard intravenous paracetamol postoperatively.

Active_comparator: External Oblique Intercostal Block Group

Participants in this arm will receive bilateral external oblique intercostal (EOI) block after induction of general anesthesia. Under ultrasound guidance, 0.25% bupivacaine (20 mL per side; total 40 mL) will be injected into the fascial plane between the external oblique and intercostal muscles. Standard intravenous paracetamol will be administered postoperatively.

Active_comparator: Control Group - IV PCA Tramadol

Participants in this arm will receive intravenous patient-controlled analgesia (PCA) with tramadol for postoperative pain management. The PCA pump will be set to a maximum dose of 400 mg tramadol in 24 hours. Standard intravenous paracetamol (1 g every 8 hours) will also be administered. No regional anesthesia block will be performed in this group.

Related Therapeutic Areas

Gallbladder Removal

Acute Pain

Endoscopy

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