Analgesic Efficacy of Low-Volume Versus Standard-Volume 0.25% Bupivacaine for Ultrasound-Guided External Oblique and Rectus Abdominis Plane Block in Laparoscopic Cholecystectomy, A Randomized Non-Inferiority Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The original EXORA block used high local anesthetic volume (50 mL total), raising concerns about local anesthetic systemic toxicity (LAST). In such a bilaterally administered regional technique, evaluating the efficacy of a reduced-volume approach is warranted to maximize patient safety.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• American Society of Anesthesiologists (ASA) physical status I or II.
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia.
Locations
Other Locations
Egypt
Fayoum University hospital
RECRUITING
El Fayoum Qesm
Contact Information
Primary
Mohammed R Gomaa, Bch
mr147@fayoum.edu.eg
1097830069
Backup
Mohamed H Ragab, MD
mhr02@fayoum.edu.eg
1090050298 Ext. +20
Time Frame
Start Date: 2026-04-12
Estimated Completion Date: 2027-01-02
Participants
Target number of participants: 96
Treatments
Active_comparator: EXORA 15
15 mL of bupivacaine 0.25% administered bilaterally
Active_comparator: EXORA 25
25 mL of bupivacaine 0.25% administered bilaterally
Related Therapeutic Areas
Sponsors
Leads: Fayoum University Hospital