Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients. A Prospective, Multicentric, Randomized, Controlled Trial.

Status: Unknown
Location: See all (4) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

In patients with type 2 diabetes, Roux-en-Y gastric bypass (RYGB), which excludes a portion of the stomach and the proximal intestine from the alimentary circuit, improves glucose metabolism more rapidly and more extensively than is expected from weight loss. The mechanisms of this unique effect of gastrointestinal exclusion appear to be complex and have not yet been clarified. A recent study unveil that intestinal uptake of ingested glucose is diminished by RYGB and restricted to the common limb, where food meets bile and other digestive fluids, resulting in an overall decrease of post prandial blood glucose excursion. the hypothesize that reducing the length of the common limb, which is rarely measured and highly variable in clinical practice, may significantly affect the metabolic outcome of gastrointestinal surgical procedures. The aim of the present study is to compare the impact of two variants of Roux-en-Y gastric bypass with a short common limb, the long alimentary limb or the long biliary limb Roux-en-Y gastric bypass, on type 2 diabetes remission in severely obese patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: f
View:

• BMI ≥ 35 kg/m2

• All patient with type 2 diabetes

• Patients who were candidates for obesity surgery in accordance with French recommendation

Locations
Other Locations
France
Chu Amiens Picardie
RECRUITING
Amiens
Ch Boulogne-Sur-Me
RECRUITING
Boulogne-sur-mer
Hop Claude Huriez Chu Lille
RECRUITING
Lille
Ch de Valenciennes
RECRUITING
Valenciennes
Contact Information
Primary
Grégory BAUD, MD
gregory.baud@chru-lille.fr
3.20.44.42.73
Time Frame
Start Date: 2019-06-16
Completion Date: 2024-06
Participants
Target number of participants: 396
Treatments
Sham_comparator: Standard Roux-en-Y
Active_comparator: Long alimentary limb Roux-en-Y
Related Therapeutic Areas
Sponsors
Collaborators: Ministry of Health, France
Leads: University Hospital, Lille

This content was sourced from clinicaltrials.gov

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