The Effects of Bariatric Surgeries on Glucose Metabolism
Who is this study for? Patients with Gastric Bypass, Sleeve Gastrectomy
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:
• Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
• Asymptomatic individuals with bariatric surgery
• Healthy non-surgical patients with no personal history of diabetes
• Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
Locations
United States
Texas
South Texas Veterans Health Care System
RECRUITING
San Antonio
Texas Diabetes Institute - University Health System
RECRUITING
San Antonio
Contact Information
Primary
Marzieh Salehi, MD MS
salehi@uthscsa.edu
210-567-6691
Backup
Jennifer Foster, MSN
fosterj6@uthscsa.edu
210-450-8696
Time Frame
Start Date: 2015-07
Estimated Completion Date: 2027-08
Participants
Target number of participants: 200
Treatments
Experimental: Exendin-(9-39)
To evaluate the role of GLP-1 on glucose metabolism and insulin secretin after glucose and protein ingestion.
Experimental: Atropine
to evaluate the effect of neural activation on insulin secretion and glucose metabolism
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: The University of Texas Health Science Center at San Antonio