Ticagrelor-Based Dual Antiplatelet Therapy in Coronary Artery Bypass Grafting: A Randomized Clinical Trial on Graft Patency

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized controlled trial aims to evaluate the impact of different durations of Ticagrelor-based dual antiplatelet therapy (DAPT) on saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass grafting (CABG). A total of 300 patients will be randomly assigned to receive Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, 6 months, or 12 months, followed by aspirin monotherapy.The primary outcome is 1-year graft patency, assessed via coronary CT angiography. Secondary outcomes include bleeding events (BARC classification), major adverse cardiovascular and cerebrovascular events (MACCE), and all-cause mortality. The study aims to determine the optimal DAPT duration to balance graft patency benefits and bleeding risks, ultimately guiding postoperative antiplatelet strategies for CABG patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• Patients 18-80 of age.

• Patients undergo planned CABG for the first time with ≥1 SVGs

• Patients with written informed consent.

Locations
Other Locations
China
the Second Hospital of Jilin University
RECRUITING
Changchun
Contact Information
Primary
kexiang liu
kxliu64@hotmail.com
17390920328
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2026-03-20
Participants
Target number of participants: 300
Treatments
Active_comparator: 3-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 3 months, followed by aspirin monotherapy
Active_comparator: 6-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 6 months, followed by aspirin monotherapy
Experimental: 12-Month DAPT Group
Ticagrelor (90 mg BID) + Aspirin (100 mg QD) for 12 months, followed by aspirin monotherapy
Sponsors
Leads: Kexiang Liu, MD

This content was sourced from clinicaltrials.gov