Single Versus Dual Antiplatelet Therapy in Patients With Incomplete Revascularization After Coronary Artery Bypass Graft Surgery

Who is this study for? Adult patients with Coronary Artery Disease
What treatments are being studied? Ticagrelor
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The study aims to compare the efficacy of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) in patients with incomplete revascularization after coronary artery bypass graft surgery (CABG). Before hospital discharge, patients will be 1:1 randomized to SAPT (acetylsalicylic acid 100 mg/die) or DAPT (acetylsalicylic acid 100 mg/die + ticagrelor 90 mg bis in die). DAPT will be continued for 12 months, and ticagrelor will be withdrawn thereafter. Primary endpoint is the evaluation of cardiac-related mortality at 5 years from hospital discharge.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• patients undergoing CABG, ± cardiopulmonary bypass, ± any associated cardiac procedures (valve replacement,...)

• incomplete myocardial revascularization, defined by anatomic or functional criteria

• obtained informed consent

Locations
Other Locations
Italy
Università Campus Bio-Medico di Roma
RECRUITING
Rome
Contact Information
Primary
Antonio Nenna, MD
a.nenna@unicampus.it
+393337014743
Backup
Massimo Chello, MD
m.chello@unicampus.it
Time Frame
Start Date: 2019-01-02
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 800
Treatments
Experimental: DAPT
Dual antiplatelet therapy: acetylsalicylic acid 100 mg/die + ticagrelor 90 mg bis in die
Active_comparator: SAPT
Single antiplatelet therapy: acetylsalicylic acid 100 mg/die
Sponsors
Leads: Campus Bio-Medico University

This content was sourced from clinicaltrials.gov