A Comparison Between the Effect of Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia on Cerebral Perfusion Guided by Near Infra-red Spectroscopy in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Graft Surgery: (A Randomized Controlled Study)
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 21
Healthy Volunteers: f
View:
• patients with coronary artery disease
• with moderate to severe left ventricular dysfunction (ejection fraction \< 40%),
• scheduled for elective CABG surgery
Locations
Other Locations
Egypt
Kasr Alainy Hospital
RECRUITING
Cairo
Contact Information
Primary
Maha Mostafa
maha.mostafa@cu.edu.eg
+201000365115
Time Frame
Start Date: 2025-12-01
Estimated Completion Date: 2026-07
Participants
Target number of participants: 40
Treatments
Active_comparator: fentanyl group
fentanyl bolus during induction of anesthesia
Active_comparator: lidocaine group
lidocaine bolus during the induction of anesthesia
Related Therapeutic Areas
Sponsors
Leads: Cairo University