Effect of Dapagliflozin on Right Ventricular-Pulmonary Artery Coupling After Off-Pump Coronary Artery Bypass Grafting: a Prospective Single-Center Study
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
This prospective, single-center observational study evaluates the effect of dapagliflozin 10 mg/day on right ventricular-pulmonary artery coupling measured by the TAPSE/PASP ratio in 72 patients with left ventricular ejection fraction \<50% after off-pump coronary artery bypass grafting (OPCAB). The primary outcome is the change in TAPSE/PASP ratio from 1 month after surgery (before dapagliflozin) to 7 months after surgery (after 6 months of dapagliflozin therapy).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥ 18 years
• Elective isolated off-pump coronary artery bypass grafting (OPCAB)
• Left ventricular ejection fraction (LVEF) \< 50% documented on pre-operative echocardiography
• Written informed consent
Locations
Other Locations
Russian Federation
Pyatigorsk City Clinical Hospital Number 1
RECRUITING
Pyatigorsk
Contact Information
Primary
Samson S. Badalyan, MD, PhD
sambadalyan@mail.ru
+79614972949
Backup
Syune V. Markosyan, MD.
ssm8883@gmail.com
+79633876510
Time Frame
Start Date: 2026-07-01
Estimated Completion Date: 2028-07-01
Participants
Target number of participants: 72
Treatments
Dapagliflozin Group
Patients receiving dapagliflozin 10 mg once daily starting at 1 month after off-pump CABG
Related Therapeutic Areas
Sponsors
Leads: Pyatigorsk City Clinical Hospital Number 1