Comparison of the Postoperative Analgesic Effects of Intrathecal Morphine and Bi-level Erector Spinae Plane Block in Liver Transplantation Donors

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes. Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects. In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Patients aged 18-65 years

• American Society of Anesthesiologists (ASA) score I-II

• Body Mass Index (BMI) between 18-30 kg/m2

Locations
Other Locations
Turkey
Ankara Etlik City Hospital
RECRUITING
Altındağ
Contact Information
Primary
Atakan Sezgi
kansezgi@gmail.com
00905323327000
Backup
Jülide Ergil
julideergil@hotmail.com
00905323469216
Time Frame
Start Date: 2025-08-18
Estimated Completion Date: 2026-07-24
Participants
Target number of participants: 60
Treatments
Active_comparator: Intrathecal Morphine
An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level.~In the intraoperative period, intravenous meperidine 0.5 mg/kg will be given 30min before the end of surgery.
Active_comparator: Bi-level Erector Spinae Plane Block
After the linear ultrasound (US) probe will be placed 2-3 cm lateral to the T8 spinous process, 10 ml of 0.25% bupivacaine hydrochloride will be injected cauda-cranially into the interfacial space below the erector spinae muscle, above the transverse process. Next, the needle will be withdrawn till subcutaneously and the linear US probe will be placed 2-3 cm lateral to the T10 spinous process. Finally, 10 ml of 0.25% bupivacaine hydrochloride will be injected cranio-caudally into the interfacial space below the erector spinae muscle, above the transverse process.~This procedure will be performed bilaterally. A total of 40 ml of 0.25% bupivacaine will be injected for bilateral and bi-level ESPB application.~In the intraoperative period, intravenous meperidine 0.5 mg/kg will be given 30min before the end of surgery.
Sponsors
Leads: Ankara Etlik City Hospital

This content was sourced from clinicaltrials.gov