A Randomized Controlled Trial of Methylprednisolone Versus Standard of Care in Patients Undergoing Major Hepatectomy
Status: Recruiting
Location: See all (19) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
The purpose of this study is to test whether receiving methylprednisolone before surgery will reduce the side effects of having surgery, such as infections and longer hospital stays.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥18 years at the time of consent.
• Scheduled to undergo elective major hepatectomy (defined by CPT codes 47122 \[trisegmentectomy\], 47125 \[total left hepatectomy\], or 47130 \[total right hepatectomy\]).
• In addition to major hepatectomy, as defined above, patients may undergo additional partial hepatectomy or operative ablation.
Locations
United States
Iowa
UNIVERSITY OF IOWA (Data Collection Only)
NOT_YET_RECRUITING
Iowa City
Illinois
Rush University Medical Center (Data collection only)
NOT_YET_RECRUITING
Chicago
University of Chicago (Data Collection Only)
NOT_YET_RECRUITING
Chicago
Indiana
Indiana University (Data Collection Only)
NOT_YET_RECRUITING
Indianapolis
Kentucky
University of Kentucky (Data Collection Only)
NOT_YET_RECRUITING
Lexington
Michigan
Henry Ford Hospital (Data collection only)
NOT_YET_RECRUITING
Detroit
Minnesota
Mayo Clinic (Data Collection Only)
NOT_YET_RECRUITING
Rochester
Missouri
Washington University (Data Collection Only)
NOT_YET_RECRUITING
St Louis
North Carolina
Duke University (Data Collection Only)
NOT_YET_RECRUITING
Durham
Nebraska
University of Nebraska Medical Center (Data Collection Only)
NOT_YET_RECRUITING
Omaha
New Jersey
Rutgers University (Data Collection Only)
NOT_YET_RECRUITING
New Brunswick
New York
Memorial Sloan Kettering Commack (Data Collection Only)
RECRUITING
Commack
Memoral Sloan Kettering Westchester (Data Collection Only)
RECRUITING
Harrison
Northwell Health (Data collection only)
NOT_YET_RECRUITING
Manhasset
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING
New York
New York University (Data Collection Only)
NOT_YET_RECRUITING
New York
SUNY Upstate Medical University
NOT_YET_RECRUITING
Syracuse
Wisconsin
Gundersen Lutheran Medical Foundation (Data Collection Only)
NOT_YET_RECRUITING
La Crosse
University of Wisconsin (Data Collection Only)
NOT_YET_RECRUITING
Madison
Contact Information
Primary
Michael D'Angelica, MD
dangelim@MSKCC.ORG
212-639-3226
Backup
Peter Kingham, MD
kinghamP@mskcc.org
212-639-5260
Time Frame
Start Date: 2026-03-27
Estimated Completion Date: 2029-03-27
Participants
Target number of participants: 750
Treatments
Experimental: Cohort 1: Methylprednisolone
No_intervention: Cohort 2: No Steroid
Related Therapeutic Areas
Sponsors
Leads: Memorial Sloan Kettering Cancer Center