Clinical trials related to Hormone Replacement Therapy (HRT) Procedure
Correlation Between Endometrial Peristalsis And Pregnancy Outcomes In Patients Undergoing Frozen Embryo Transfer With Hormone Replacement Therapy for Endometrial Preparation Protocol
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY
Endometrial peristalsis may influence embryo implantation and pregnancy outcomes, but its role during hormone replacement therapy (HRT)-prepared frozen embryo transfer (FET) cycles remains unclear. This prospective observational study will assess endometrial peristalsis at predefined time points during HRT-prepared FET cycles using transvaginal ultrasonography and evaluate its association with pregnancy outcomes. The study aims to clarify the clinical significance of endometrial peristalsis in HRT-prepared FET cycles and to provide evidence supporting endometrial assessment in assisted reproductive technology.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 42
Healthy Volunteers: f
View:
• Women aged 18 - 42 years old
• Scheduled for frozen embryo transfer cycles using hormone replacement therapy protocol
• Transferred no more than two cleavage embryos or one good-quality blastocyst or no more than two poor-quality blastocysts
• Provision of written informed consent to participate
Locations
Other Locations
Viet Nam
IVFMD - My Duc Hospital
RECRUITING
Ho Chi Minh City
Contact Information
Primary
Nhi NL Ho, MD
drnhiho@gmail.com
+84903497611
Backup
Vu NA Ho, MD, PhD
bsvu.hna@myduchospital.vn
+84935843336
Time Frame
Start Date:2026-06-30
Estimated Completion Date:2027-12-01
Participants
Target number of participants:442
Treatments
Exogenous steroid protocol
The endometrium will be prepared with the use of oral estradiol valerate (Progynova®; Delpharm Lille SAS, France, or Valiera®, Laboratorios Recalcine) at a dose of 6 mg per day, starting on the second, third, or fourth day of the menstrual cycle. Endometrial thickness will be monitored from day 10 onward, and vaginal progesterone (Cyclogest, LD Collins, UK) at 800 mg per day and dydrogesterone (Duphaston, Abbott Biologicals B.V, US) at 20 mg per day will be started when the endometrial thickness reaches 8 mm or more. Embryo transfer was performed at 4 days for cleavage embryo transfer or at 6 days for blastocyst embryo transfer, after progesterone was started. All embryos were warmed on the day of transfer. Vaginal progesterone administration will be maintained until the day of the pregnancy test. In the event of a positive test result, luteal phase support will be extended until 10 weeks of gestation.